{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T19:19:58Z","timestamp":1791141598115,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2014,6,5]],"date-time":"2014-06-05T00:00:00Z","timestamp":1401926400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Department of Science and Technology (DST), New Delhi","award":["SERB\/F\/4302\/2012-13"],"award-info":[{"award-number":["SERB\/F\/4302\/2012-13"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2014,10]]},"abstract":"<jats:p>\n                    The present study reported the synthesis and biologic evaluation of new pyrazolone derivatives for COX\u20102 inhibitory activities and investigated\n                    <jats:italic>in vivo<\/jats:italic>\n                    for their anti\u2010inflammatory activities using carrageenan\u2010induced rat paw edema model as well as\n                    <jats:italic>in vitro<\/jats:italic>\n                    using HRBC membrane stabilization and protein denaturation method. Eight derivatives showed pronounced COX\u20102 inhibition, and\n                    <jats:bold>5a, 5d,<\/jats:bold>\n                    and\n                    <jats:bold>5f<\/jats:bold>\n                    exhibited the highest COX\u20102 inhibition. The derivatives were further evaluated for antioxidant activity wherein\n                    <jats:bold>5a<\/jats:bold>\n                    and\n                    <jats:bold>5b<\/jats:bold>\n                    showed potent free radical\u2010scavenging activity against DPPH, nitric oxide, and hydrogen peroxide radicals. Molecular docking study revealed the binding orientations of pyrazolone derivatives into the active sites of COX\u20102 and thereby helps to design the potent inhibitors.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.12324","type":"journal-article","created":{"date-parts":[[2014,3,18]],"date-time":"2014-03-18T06:33:06Z","timestamp":1395124386000},"page":"409-419","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and Biologic Evaluation of Substituted 5\u2010methyl\u20102\u2010phenyl\u20101H\u2010pyrazol\u20103(2H)\u2010one Derivatives as Selective COX\u20102 Inhibitors: Molecular Docking Study"],"prefix":"10.1111","volume":"84","author":[{"given":"Pritam N.","family":"Dube","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy Dr. Rafiq Zakaria Campus Aurangabad\u2010431001 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shweta S.","family":"Bule","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry S.M.B.T. College of Pharmacy Dhamangaon Nashik\u2010422403 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santosh N.","family":"Mokale","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Y. B. Chavan College of Pharmacy Dr. Rafiq Zakaria Campus Aurangabad\u2010431001 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj R.","family":"Kumbhare","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry S.M.B.T. College of Pharmacy Dhamangaon Nashik\u2010422403 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pravin R.","family":"Dighe","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry S.M.B.T. College of Pharmacy Dhamangaon Nashik\u2010422403 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh V.","family":"Ushir","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry S.M.B.T. College of Pharmacy Dhamangaon Nashik\u2010422403 Maharashtra India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,6,5]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"751","volume-title":"Non\u2010Steroidal Anti\u2010Inflammatory Drugs, Foye's Principles of Medicinal Chemistry","author":"Williams D.A.","year":"2002"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0167-5699(91)90009-I"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.09.005"},{"key":"e_1_2_7_5_1","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archinte.1992.00400180017003","article-title":"Effects of nonsteroidal anti\u2010inflammatory drugs on endogenous gastrointestinal prostaglandins and therapeutic strategies for prevention and treatment of nonsteroidal anti\u2010inflammatory drug\u2010induced damage","volume":"152","author":"Cryer B.","year":"1992","journal-title":"Arch Intern Med"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(01)01197-7"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13271"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.02.043"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2011.11.012"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.08.005"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1039\/b803608j"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm901269y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/384644a0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2005.09.006"},{"key":"e_1_2_7_15_1","first-page":"1150","volume-title":"Textbook of Practical Organic Chemistry","author":"Furniss B.S.","year":"2007"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-969503"},{"key":"e_1_2_7_17_1","first-page":"19","article-title":"Microscope Evaluation sanctum and Ocimum basillicum Seeds","volume":"3","author":"Ushir Y.V.","year":"2011","journal-title":"Inventi Rapid: Planta Activa"},{"key":"e_1_2_7_18_1","first-page":"109","article-title":"Evaluation of in\u2010vitro anti\u2010inflammatory activity of herbal preparation, a combination of four herbal plants","volume":"2","author":"Padmanabhan P.","year":"2012","journal-title":"Int J Basic App Med Sci"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-3879"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2009.05.039"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.02.077"},{"key":"e_1_2_7_22_1","first-page":"684","article-title":"Synthesis and Biological Evaluation of 3\u2010Amino Pyrazolones","volume":"23","author":"Galla R.","year":"2011","journal-title":"Asian J Chem"},{"key":"e_1_2_7_23_1","first-page":"131","article-title":"Analysis of nitrate, nitrite, and [15N]nitrate in biological fluids","volume":"2","author":"Green L.C.","year":"1982","journal-title":"Anal Biol Chem"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/10.6.1003"},{"key":"e_1_2_7_25_1","unstructured":"Maestro version 9.3 Schr\u00f6dinger LLC New York NY 2012."},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ardp.19963291007"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2009.07.004"},{"key":"e_1_2_7_28_1","doi-asserted-by":"crossref","first-page":"1564","DOI":"10.1055\/s-0030-1249779","article-title":"Anti\u2010inflammatory, cyclooxygenase (COX)\u20102, COX\u20101 inhibitory, and free radical scavenging effects of Rumex nepalensis","volume":"76","author":"Gautam R.","year":"2010","journal-title":"Planta Med"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12324","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T13:26:34Z","timestamp":1696339594000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,6,5]]},"references-count":27,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2014,10]]}},"alternative-id":["10.1111\/cbdd.12324"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12324","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,6,5]]}}}