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This approach chemically links two pharmacophores, each with their own antimalarial activity and ideally with different modes of action, into a single hybrid molecule with the goal to improve therapeutic properties. In this paper, we report the synthesis of novel 7\u2010chloro\u20104\u2010aminoquinoline\/primary sulfonamide hybrid compounds. The chlorinated 4\u2010aminoquinoline scaffold is the core structure of chloroquine, an established antimalarial drug, while the primary sulfonamide functional group has a proven track record of efficacy and safety in many clinically used drugs and was recently shown to exhibit some antimalarial activity. The activity of the hybrid compounds was determined against chloroquine\u2010sensitive (3D7) and chloroquine\u2010resistant (Dd2) <jats:italic>Plasmodium falciparum<\/jats:italic> strains. While the hybrid compounds had lower antimalarial activity when compared to chloroquine, they demonstrated a number of interesting structure\u2013activity relationship (SAR) trends including the potential to overcome the resistance profile of chloroquine.<\/jats:p>","DOI":"10.1111\/cbdd.12335","type":"journal-article","created":{"date-parts":[[2014,4,10]],"date-time":"2014-04-10T23:42:26Z","timestamp":1397173346000},"page":"462-472","source":"Crossref","is-referenced-by-count":22,"title":["Synthesis and Evaluation of Antimalarial Properties of Novel 4\u2010Aminoquinoline Hybrid Compounds"],"prefix":"10.1111","volume":"84","author":[{"given":"Gillian M.","family":"Fisher","sequence":"first","affiliation":[{"name":"Eskitis Institute for Drug Discovery Griffith University Don Young Road Nathan Qld 4111 Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rajendra P.","family":"Tanpure","sequence":"additional","affiliation":[{"name":"Eskitis Institute for Drug 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