{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T12:57:33Z","timestamp":1788872253547,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2014,7,16]],"date-time":"2014-07-16T00:00:00Z","timestamp":1405468800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"College of Health Science, University of KwaZulu-Natal, Durban, South Africa","award":["CS78"],"award-info":[{"award-number":["CS78"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2014,11]]},"abstract":"<jats:p>\n                    Herein, we report synthesis and screening of a series of twenty derivatives of bromopyrrole alkaloids with aroyl hydrazone feature for antidepressant activity by\n                    <jats:italic>forced swim test<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>\n                    ),\n                    <jats:italic>tail suspension test<\/jats:italic>\n                    (\n                    <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>\n                    ), and actophotometer method. The molecules were further evaluated for\n                    <jats:italic>in vitro<\/jats:italic>\n                    human\n                    <jats:styled-content style=\"fixed-case\">MAO<\/jats:styled-content>\n                    's inhibitory activities. The tested compounds exhibited moderate to good antidepressant activity compared with standard fluoxetine. Among these, most promising antidepressant derivatives\n                    <jats:bold>5b<\/jats:bold>\n                    (%\n                    <jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>\n                    \u00a0=\u00a060.48),\n                    <jats:bold>5e<\/jats:bold>\n                    (%\n                    <jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>\n                    \u00a0=\u00a059), and\n                    <jats:bold>5j<\/jats:bold>\n                    (%\n                    <jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>\n                    \u00a0=\u00a074.86) reduced immobility duration of 50\u201370% at 30\u00a0mg\/kg dose levels in\n                    <jats:styled-content style=\"fixed-case\">FST<\/jats:styled-content>\n                    . Further, derivative\n                    <jats:bold>5b<\/jats:bold>\n                    ,\n                    <jats:bold>5e,<\/jats:bold>\n                    and\n                    <jats:bold>5j<\/jats:bold>\n                    displayed good antidepressant activity with %\n                    <jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>\n                    value of 47.50, 46.62, and 52.49, respectively, in\n                    <jats:styled-content style=\"fixed-case\">TST<\/jats:styled-content>\n                    compared with standard fluoxetine (66.56%\n                    <jats:styled-content style=\"fixed-case\">DID<\/jats:styled-content>\n                    ). Compound\n                    <jats:bold>5b<\/jats:bold>\n                    showed high\n                    <jats:italic>in vitro<\/jats:italic>\n                    <jats:styled-content style=\"fixed-case\">MAO<\/jats:styled-content>\n                    \u2010A potency and selectivity (\n                    <jats:italic>K<\/jats:italic>\n                    <jats:sub>i<\/jats:sub>\n                    <jats:styled-content style=\"fixed-case\">MAO<\/jats:styled-content>\n                    \u2010A (\n                    <jats:italic>\u03bc<\/jats:italic>\n                    <jats:sc>m<\/jats:sc>\n                    )\u00a0=\u00a02.4\u00a0\u00b1\u00a00.99,\n                    <jats:styled-content style=\"fixed-case\">SI<\/jats:styled-content>\n                    \u00a0=\u00a00.06) with promising pharmacological activity recognizing its potential as antidepressant lead candidate for further drug development. Study revealed that the presence of halogen atoms such as chlorine and fluorine at\n                    <jats:italic>ortho<\/jats:italic>\n                    \u2010 and\/or\n                    <jats:italic>para<\/jats:italic>\n                    \u2010position of phenyl ring and\n                    <jats:italic>N<\/jats:italic>\n                    \u2010alkylation of pyrrole core is favored features for antidepressant activity.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.12352","type":"journal-article","created":{"date-parts":[[2014,5,2]],"date-time":"2014-05-02T11:32:57Z","timestamp":1399030377000},"page":"593-602","source":"Crossref","is-referenced-by-count":10,"title":["Synthesis and Evaluation of Novel Marine Bromopyrrole Alkaloid\u2010Based Derivatives as Potential Antidepressant Agents"],"prefix":"10.1111","volume":"84","author":[{"given":"Rajesh A.","family":"Rane","sequence":"first","affiliation":[{"name":"Discipline of Pharmaceutical Sciences College of Health Sciences University of KwaZulu\u2010Natal Durban 4001 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shital","family":"Napahde","sequence":"additional","affiliation":[{"name":"Piramal Health Care Ltd Goregaon Mumbai 400 063 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pavan Kumar","family":"Bangalore","sequence":"additional","affiliation":[{"name":"S. P. P. School of Pharmacy and Technology Management NMIMS University Vile Parle Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niteshkumar U.","family":"Sahu","sequence":"additional","affiliation":[{"name":"S. P. P. School of Pharmacy and Technology Management NMIMS University Vile Parle Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Shah","sequence":"additional","affiliation":[{"name":"S. P. P. School of Pharmacy and Technology Management NMIMS University Vile Parle Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yogesh A.","family":"Kulkarni","sequence":"additional","affiliation":[{"name":"S. P. P. School of Pharmacy and Technology Management NMIMS University Vile Parle Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kalyani","family":"Barve","sequence":"additional","affiliation":[{"name":"S. P. P. School of Pharmacy and Technology Management NMIMS University Vile Parle Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leena","family":"Lokare","sequence":"additional","affiliation":[{"name":"S. P. P. School of Pharmacy and Technology Management NMIMS University Vile Parle Mumbai 400056 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rajshekhar","family":"Karpoormath","sequence":"additional","affiliation":[{"name":"Discipline of Pharmaceutical Sciences College of Health Sciences University of KwaZulu\u2010Natal Durban 4001 South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,7,16]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2006.07.002"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00004714-200302000-00011"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1846"},{"key":"e_1_2_8_5_1","first-page":"283","volume-title":"Principles of Medicinal Chemistry","author":"Nieforth K.A.","year":"1995"},{"key":"e_1_2_8_6_1","first-page":"2486","article-title":"Potential psychotropic agents. I. Synthesis of 1\u2010(2\u2010indolylcarbonyl)\u20102\u2010alkylhydrazines, 1\u2010(3\u2010indolylcarbonyl)\u20102\u2010alkylhydrazines and 1\u2010(3\u2010indolylacetyl)\u20102\u2010alkylhydrazines, and measurement, in vitro, of their monoamine oxidase inhibitory activity","volume":"8","author":"Alemany A.","year":"1996","journal-title":"Bull Soc Chim Fr"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060882y"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568026613666131216110001"},{"key":"e_1_2_8_9_1","first-page":"271","volume-title":"Modern Alkaloids Structure, Isolation, Synthesis and Biology","author":"Aiello A.","year":"2008"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2007.07.032"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00573.x"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.200700774"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.03.029"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.09.073"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.3109\/14756366.2013.793183"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm030479g"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0400810"},{"issue":"2","key":"e_1_2_8_18_1","first-page":"ii45","article-title":"Safety and tolerability of linezolid","volume":"51","author":"French G.","year":"2003","journal-title":"J Anti micro Chemother"},{"key":"e_1_2_8_19_1","first-page":"105","article-title":"Pharmacological screening of Isatin\u2010[N\u2010(2\u2010alkylbenzoxazole\u20105\u2010carbonyl)] hydrazones","volume":"59","author":"Saragapani M.","year":"1997","journal-title":"Ind. J Pharm Sci"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2011.05.056"},{"key":"e_1_2_8_21_1","first-page":"185","article-title":"Hydrazidehydrazone derivatives as antidepressant, sedative and analgesic agents","volume":"2","author":"Mohareb R.M.","year":"2010","journal-title":"J Pharm Sci & Res"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0223-5234(98)80039-1"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.08.061"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00269a019"},{"key":"e_1_2_8_25_1","first-page":"327","article-title":"Behavioral despair in mice: a primary screening test for antidepressants","volume":"229","author":"Porsolt R.D.","year":"1977","journal-title":"Arch Int Pharmacodyn Ther"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.07.041"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.02.026"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00428203"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2009.09.014"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(65)90025-0"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.12.108"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2013.09.039"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12352","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:19:55Z","timestamp":1696349995000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,7,16]]},"references-count":31,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2014,11]]}},"alternative-id":["10.1111\/cbdd.12352"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12352","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,7,16]]}}}