{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T21:40:57Z","timestamp":1781127657051,"version":"3.54.1"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2014,9,5]],"date-time":"2014-09-05T00:00:00Z","timestamp":1409875200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003010","name":"Ege University","doi-asserted-by":"crossref","award":["2009NBE010"],"award-info":[{"award-number":["2009NBE010"]}],"id":[{"id":"10.13039\/501100003010","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2015,3]]},"abstract":"<jats:p>In this study, radiolabeling of a bisphosphonate, alendronate (Alendronate sodium), was performed with the help of a bifunctional chelating agent. For that purpose, <jats:styled-content style=\"fixed-case\">DTPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> (Diethylenetriaminepentaacetic acid dianhydride\u2010N\u2010hydroxysuccinimide) was synthesized with an esterification between <jats:styled-content style=\"fixed-case\">DTPA<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content>. Combining the <jats:styled-content style=\"fixed-case\">DTPA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> ester with alendronate yields the <jats:styled-content style=\"fixed-case\">DTPA<\/jats:styled-content>\u2010Alendronate compound. The structure of synthesized compound was analyzed by <jats:sup>1<\/jats:sup>H\/<jats:sup>13<\/jats:sup>C\/<jats:sup>31<\/jats:sup>P\u2010<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">HPLC<\/jats:styled-content>. After then, the labeling with [<jats:sup>99m<\/jats:sup>Tc(<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>)<jats:sub>3<\/jats:sub>]<jats:sup>+<\/jats:sup> core of synthesized compound was provided. Performing quality controls of newly synthesized [<jats:sup>99m<\/jats:sup>Tc(<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>)<jats:sub>3<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">DTPA<\/jats:styled-content>\u2010Alendronate] complex with thin layer radiochromatography (<jats:styled-content style=\"fixed-case\">TLRC<\/jats:styled-content>) and high\u2010performance liquid radiochromatography (<jats:styled-content style=\"fixed-case\">HPLRC<\/jats:styled-content>), the labeling yield was found as 99%. It was observed that the compound conserves its stability for 24\u00a0h in serum media. Biodistribution of the radiolabeled complex was performed on Wistar Albino rats to determine radiopharmaceutical potential of the [<jats:sup>99m<\/jats:sup>Tc(<jats:styled-content style=\"fixed-case\">CO<\/jats:styled-content>)<jats:sub>3<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">DTPA<\/jats:styled-content>\u2010Alendronate] complex. It is thought that the data gained from this study will contribute to the development of complexes with bisphosphonate.<\/jats:p>","DOI":"10.1111\/cbdd.12401","type":"journal-article","created":{"date-parts":[[2014,8,5]],"date-time":"2014-08-05T08:57:04Z","timestamp":1407229024000},"page":"369-376","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis and Biological Evaluation of Bisphosphonate Compound Labeled with <sup>99m<\/sup><scp>T<\/scp>c(<scp>CO<\/scp>)<sub>3<\/sub><sup>+<\/sup>"],"prefix":"10.1111","volume":"85","author":[{"given":"Kamile","family":"\u015eenocak","sequence":"first","affiliation":[{"name":"Ege University Institute of Nuclear Sciences Bornova Izmir 35100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Serap","family":"Teks\u00f6z","sequence":"additional","affiliation":[{"name":"Ege University Institute of Nuclear Sciences Bornova Izmir 35100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00c7i\u011fdem","family":"\u0130\u00e7hedef","sequence":"additional","affiliation":[{"name":"Ege University Institute of Nuclear Sciences Bornova Izmir 35100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eser","family":"U\u00e7ar","sequence":"additional","affiliation":[{"name":"Ege University Institute of Nuclear Sciences Bornova Izmir 35100 Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,9,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2006.03.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00775-007-0215-0"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2008.11.007"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2011.02.015"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2007-0245"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.4065\/83.9.1032"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/bcr414"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.beem.2008.07.001"},{"key":"e_1_2_7_10_1","first-page":"5433","article-title":"Antitumor activity of bisphosphonates","volume":"9","author":"Smith M.R.","year":"2003","journal-title":"Clin Cancer Res"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.12.004"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apradiso.2010.03.009"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nucmedbio.2010.12.005"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0305-7372(02)00095-6"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S8756-3282(99)00116-7"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1039\/c0dt01396j"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja980745t"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10967-011-1164-1"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/b908652h"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlcr.1455"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0969-8051(96)00151-5"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12401","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12401","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T00:50:38Z","timestamp":1696294238000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12401"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,9,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,3]]}},"alternative-id":["10.1111\/cbdd.12401"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12401","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,9,5]]}}}