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Benzimidazole derivatives are useful intermediates\/subunits for the development of molecules of pharmaceutical or biological interest. Substituted benzimidazole derivatives have found applications in diverse therapeutic areas such as antiulcer, anticancer agents, and anthelmintic species to name just a few. This work systematically gives a comprehensive review in current developments of benzimidazole\u2010based compounds in the whole range of medicinal chemistry as anticancer, antibacterial, antifungal, anti\u2010inflammatory, analgesic agents, anti\u2010\n                    <jats:styled-content style=\"fixed-case\">HIV<\/jats:styled-content>\n                    , antioxidant, anticonvulsant, antitubercular, antidiabetic, antileishmanial, antihistaminic, antimalarial agents, and other medicinal agents. This review will further be helpful for the researcher on the basis of substitution pattern around the nucleus with an aim to help medicinal chemists for developing an\n                    <jats:styled-content style=\"fixed-case\">SAR<\/jats:styled-content>\n                    on benzimidazole drugs\/compounds.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.12462","type":"journal-article","created":{"date-parts":[[2014,10,28]],"date-time":"2014-10-28T11:48:40Z","timestamp":1414496920000},"page":"19-65","source":"Crossref","is-referenced-by-count":369,"title":["Comprehensive Review in Current Developments of Benzimidazole\u2010Based Medicinal Chemistry"],"prefix":"10.1111","volume":"86","author":[{"given":"Rangappa S.","family":"Keri","sequence":"first","affiliation":[{"name":"Centre for Nano and Material Sciences Jain University Jain Global Campus Bangalore Karnataka 562112 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asha","family":"Hiremathad","sequence":"additional","affiliation":[{"name":"Centre for Nano and Material Sciences Jain University Jain Global Campus Bangalore Karnataka 562112 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Srinivasa","family":"Budagumpi","sequence":"additional","affiliation":[{"name":"Centre for Nano and Material Sciences Jain University Jain Global Campus Bangalore Karnataka 562112 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhari Mallanna","family":"Nagaraja","sequence":"additional","affiliation":[{"name":"Centre for Nano and Material Sciences Jain University Jain Global Campus Bangalore Karnataka 562112 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2014,11,28]]},"reference":[{"key":"e_1_2_27_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.18720050295"},{"key":"e_1_2_27_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.187500801209"},{"key":"e_1_2_27_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cber.187801101221"},{"key":"e_1_2_27_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlac.18581070209"},{"key":"e_1_2_27_6_1","volume-title":"Imidazole and Benzimidazole Synthesis","author":"Grimmett 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