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Ca<jats:sub>V<\/jats:sub>2.2 blockers such as the <jats:italic>\u03c9<\/jats:italic>\u2010conotoxin <jats:styled-content style=\"fixed-case\">MVIIA<\/jats:styled-content> (Prialt) are analgesic and have opioid\u2010sparing effects. With the aim to develop new multitarget analgesic compounds, we designed the first <jats:italic>\u03c9<\/jats:italic>\u2010conotoxin\/opioid peptidomimetics based on the enkephalin\u2010like sequence Tyr\u2010D\u2010Ala\u2010Gly\u2010Phe (for the opioid portion) and two fragments derived from the loop\u20102 pharmacophore of <jats:italic>\u03c9<\/jats:italic>\u2010conotoxin <jats:styled-content style=\"fixed-case\">MVIIA<\/jats:styled-content>. 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