{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,10]],"date-time":"2026-02-10T11:03:46Z","timestamp":1770721426447,"version":"3.49.0"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2014,12,18]],"date-time":"2014-12-18T00:00:00Z","timestamp":1418860800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Science Foundation of China","doi-asserted-by":"crossref","award":["31172359"],"award-info":[{"award-number":["31172359"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Program for Changjiang Scholars and Innovative Research Team in University","award":["IRT13063"],"award-info":[{"award-number":["IRT13063"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2015,8]]},"abstract":"<jats:p>A series of novel hybrid molecules between sulfonamides and active antimicrobial 14\u2010o\u2010(3\u2010carboxy\u2010phenylsulfide)\u2010mutilin were synthesized, and their <jats:italic>in vitro<\/jats:italic> antibacterial activities were evaluated by the broth microdilution. Results indicated that these compounds displayed potent antimicrobial activities <jats:italic>in vitro<\/jats:italic> against various drug\u2010susceptible and drug\u2010resistant Gram\u2010positive bacteria such as <jats:italic>Staphylococci<\/jats:italic> and <jats:italic>streptococci<\/jats:italic>, including methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic>, and mycoplasma. In particular, sulfapyridine analog (<jats:bold>6c<\/jats:bold>) exhibited more potent inhibitory activity against Gram\u2010positive bacteria and mycoplasma, including <jats:italic>Staphylococcus aureus<\/jats:italic> (MIC\u00a0=\u00a00.016\u20130.063\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL), methicillin\u2010resistant <jats:italic>Staphylococcus aureus<\/jats:italic> (MIC\u00a0=\u00a00.016\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL), <jats:italic>Streptococcus pneumoniae<\/jats:italic> (MIC\u00a0=\u00a00.032\u20130.063\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL), <jats:italic>Mycoplasma gallisepticum<\/jats:italic> (MIC\u00a0=\u00a00.004\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL), with respect to other synthesized compounds and reference drugs sulfonamide (MIC\u00a0=\u00a08\u2013128\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL) and valnemulin (MIC\u00a0=\u00a00.004\u20130.5\u00a0<jats:italic>\u03bc<\/jats:italic>g\/mL). Furthermore, comparison between MIC values of pleuromutilin\u2010sulfonamide hybrids <jats:bold>6a\u2013f<\/jats:bold> with pleuromutilin parent compound <jats:bold>3<\/jats:bold> revealed that these modifications at 14 position side chain of the pleuromutilin with benzene sulfonamide could greatly improve the antibacterial activity especially against Gram\u2010positives.<\/jats:p>","DOI":"10.1111\/cbdd.12486","type":"journal-article","created":{"date-parts":[[2014,11,28]],"date-time":"2014-11-28T16:47:24Z","timestamp":1417193244000},"page":"239-245","source":"Crossref","is-referenced-by-count":18,"title":["Synthesis and Antimicrobial Activity of the Hybrid Molecules between Sulfonamides and Active Antimicrobial Pleuromutilin Derivative"],"prefix":"10.1111","volume":"86","author":[{"given":"Liangzhu","family":"Chen","sequence":"first","affiliation":[{"name":"Guangdong Dahuanong Animal Health Products Co. Ltd. Yunfu 527400 China"},{"name":"Department of Veterinary Medicine South China Agricultural University Guangzhou 510642 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dexue","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine South China Agricultural University Guangzhou 510642 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhikun","family":"Pan","sequence":"additional","affiliation":[{"name":"Guangdong Dahuanong Animal Health Products Co. Ltd. Yunfu 527400 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lihong","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine South China Agricultural University Guangzhou 510642 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianhua","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine South China Agricultural University Guangzhou 510642 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Binghu","family":"Fang","sequence":"additional","affiliation":[{"name":"Guangdong Dahuanong Animal Health Products Co. Ltd. Yunfu 527400 China"},{"name":"Department of Veterinary Medicine South China Agricultural University Guangzhou 510642 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuning","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Veterinary Medicine South China Agricultural University Guangzhou 510642 China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2014,12,18]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajic.2012.01.017"},{"key":"e_1_2_6_3_1","first-page":"535","article-title":"First isolation and detection of multiple clones of vancomycin\u2010resistant enterococci in the pediatric unit of Van Yuzuncu Yil university, Turkey","volume":"43","author":"Guducuoglu H.","year":"2009","journal-title":"Mikrobiyol Bul"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.37.9.570"},{"key":"e_1_2_6_5_1","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0021-9258(18)44820-X","article-title":"Chemical studies with pleuromutilin","volume":"199","author":"Anchel M.","year":"1952","journal-title":"J Biol Chem"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0700041104"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.915"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00338-2"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.7164\/antibiotics.29.923"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2004.11.008"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2006.08.008"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2008.09.012"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2006.08.045"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.05.011"},{"key":"e_1_2_6_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.10.123"},{"key":"e_1_2_6_16_1","first-page":"F1","article-title":"In Vitro Antibacterial spectrum of BC\u20107013, a Novel Pleuromutilin derivative for Topical use in humans","volume":"49","author":"Biedenbach D.J.","year":"2009","journal-title":"ICAAC"},{"key":"e_1_2_6_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2014.05.092"},{"key":"e_1_2_6_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2009.06.065"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12486","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12486","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T17:11:42Z","timestamp":1696266702000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12486"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2014,12,18]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2015,8]]}},"alternative-id":["10.1111\/cbdd.12486"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12486","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2014,12,18]]}}}