{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:30:58Z","timestamp":1789140658894,"version":"build-2803163510"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2015,1,16]],"date-time":"2015-01-16T00:00:00Z","timestamp":1421366400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2015,9]]},"abstract":"<jats:p>A new series of hybrid 4\u2010aminoquinoline\u20131,3,5\u2010triazine derivatives was synthesized by a four\u2010step reaction. Target compounds were screened for <jats:italic>in vitro<\/jats:italic> antimalarial activity against chloroquine\u2010sensitive (3D\u20107) and chloroquine\u2010resistant (<jats:styled-content style=\"fixed-case\">RKL<\/jats:styled-content>\u20102) strains of <jats:italic>Plasmodium falciparum<\/jats:italic>. Compounds exhibited, by and large, good antimalarial activity against the resistant strain, while two of them, that is <jats:bold>8g<\/jats:bold> and <jats:bold>8a,<\/jats:bold> displayed higher activity against both the strains of <jats:italic>P.\u00a0falciparum<\/jats:italic>. Additionally, docking study was performed on both wild (1J3I.pdb) and quadruple mutant (N51I, C59R, S108\u00a0N, I164L, 3<jats:styled-content style=\"fixed-case\">QG<\/jats:styled-content>2.pdb) type <jats:italic>pf<\/jats:italic>\u2010<jats:styled-content style=\"fixed-case\">DHFR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">TS<\/jats:styled-content> to highlight the structural features of hybrid molecules.<\/jats:p>","DOI":"10.1111\/cbdd.12490","type":"journal-article","created":{"date-parts":[[2014,12,9]],"date-time":"2014-12-09T11:13:17Z","timestamp":1418123597000},"page":"265-271","source":"Crossref","is-referenced-by-count":23,"title":["Synthesis, Docking, <i>In Vitro<\/i> and <i>In Vivo<\/i> Antimalarial Activity of Hybrid 4\u2010aminoquinoline\u20131,3,5\u2010triazine Derivatives Against Wild and Mutant Malaria Parasites"],"prefix":"10.1111","volume":"86","author":[{"given":"Hans Raj","family":"Bhat","sequence":"first","affiliation":[{"name":"Drug Design and Discovery Laboratory Department of Pharmaceutical Sciences Sam Higginbottom Institute of Agriculture Technology and Science Deemed University Allahabad 211007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Udaya Pratap","family":"Singh","sequence":"additional","affiliation":[{"name":"Drug Design and Discovery Laboratory Department of Pharmaceutical Sciences Sam Higginbottom Institute of Agriculture Technology and Science Deemed University Allahabad 211007 India"},{"name":"Nucleic Acids and Antiviral Research Laboratory Department of Chemistry University of Allahabad Allahabad 211002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Prashant","family":"Gahtori","sequence":"additional","affiliation":[{"name":"Faculty of Pharmacy Uttarakhand Technical University Dehradun 248007 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Surajit Kumar","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Dibrugarh University Dibrugarh 786004 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kabita","family":"Gogoi","sequence":"additional","affiliation":[{"name":"Regional Medical Research Centre ICMR Dibrugarh 786005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anil","family":"Prakash","sequence":"additional","affiliation":[{"name":"Regional Medical Research Centre ICMR Dibrugarh 786005 India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramendra K.","family":"Singh","sequence":"additional","affiliation":[{"name":"Nucleic Acids and Antiviral Research Laboratory Department of Chemistry University of Allahabad Allahabad 211002 India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,1,16]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"WHO. (2011)World Malaria Report."},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.1999.0426"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1586\/eri.09.68"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0968-0896(00)00022-5"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708783330575"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.182295999"},{"key":"e_1_2_6_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arabjc.2011.07.001"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2ra21915h"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3nj00317e"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm061002i"},{"key":"e_1_2_6_12_1","first-page":"627","article-title":"Synthesis, cytotoxicity and antimalarial activity of ferrocenyl amides of 4\u2010aminoquinolines","volume":"60","author":"N'Da D.D.","year":"2010","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_6_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcc.540040211"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsb921"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12490","content-type":"unspecified","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T05:32:32Z","timestamp":1696311152000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2015,1,16]]},"references-count":13,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2015,9]]}},"alternative-id":["10.1111\/cbdd.12490"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12490","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2015,1,16]]}}}