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Most of the compounds were potent with <jats:styled-content style=\"fixed-case\">IC<\/jats:styled-content><jats:sub>50<\/jats:sub> values ranging from 51.6 to 93.0\u00a0<jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc>, which are better than that of the currently marketed drug ribavirin. The molecular mechanisms of the new compounds were investigated using neuraminidase inhibition assay, cellular <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathway inhibition assay, and computational docking. Compound <jats:bold>4e<\/jats:bold>, which is a N3 imidazol\u20101\u2010ylpropyl\u2010substituted derivative of 2\u2010pyridinyl\u20104(3H)\u2010quinazolinone, had the most potent anti\u2010influenza A virus activity <jats:italic>in\u00a0vitro<\/jats:italic>, and inhibited both virus neuraminidase and cellular <jats:styled-content style=\"fixed-case\">NF<\/jats:styled-content>\u2010<jats:italic>\u03ba<\/jats:italic>B signaling pathway. In conclusion, 2\u2010pyridinyl\u20104(3H)\u2010quinazolinone is a new scaffold for the design of potent anti\u2010influenza A virus compounds, offering an alternative approach to tackle influenza drug resistance.<\/jats:p>","DOI":"10.1111\/cbdd.12589","type":"journal-article","created":{"date-parts":[[2015,5,27]],"date-time":"2015-05-27T14:44:51Z","timestamp":1432737891000},"page":"1221-1225","source":"Crossref","is-referenced-by-count":22,"title":["2\u2010Pyridinyl\u20104(3H)\u2010Quinazolinone: A Scaffold for Anti\u2010influenza A Virus Compounds"],"prefix":"10.1111","volume":"86","author":[{"given":"Shixu","family":"Liu","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Long","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengbiao","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lijuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rilei","family":"Yu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Drugs Chinese Ministry of Education School of Medicine and Pharmacy Ocean University of China Qingdao 266003 China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2015,6,15]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-008-0066-z"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1286-4579(02)00013-8"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature08182"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(13)60767-9"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2015.02.003"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201408138"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986706778773059"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.04.014"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9707277"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.06.010"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.25.1432"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.10.008"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2012.01.071"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb.26.1278"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057110384613"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057108323123"},{"key":"e_1_2_5_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2009.06.053"},{"key":"e_1_2_5_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4039(97)00651-5"},{"key":"e_1_2_5_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/0042-6822(74)90458-9"},{"key":"e_1_2_5_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2008.10.006"},{"key":"e_1_2_5_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008350"},{"key":"e_1_2_5_23_1","first-page":"5.6.1","volume-title":"Curr Protoc Bioinforma","author":"Eswar N.","year":"2006"},{"key":"e_1_2_5_24_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00959-08"},{"key":"e_1_2_5_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2011.05.009"}],"container-title":["Chemical Biology &amp; 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