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The <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content> spectra of the compounds afforded <jats:styled-content style=\"fixed-case\">NH<\/jats:styled-content> stretching (3340\u20133346 cm<jats:sup>\u22121<\/jats:sup>) bands and C=O stretching (1731\u20131746 cm<jats:sup>\u22121<\/jats:sup>). In the <jats:sup>1<\/jats:sup>H\u2010<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content> spectra of the compounds, N\u2010H protons of indoline ring were observed at 10.65\u201310.89 ppm generally as broad bands, and <jats:sup>13<\/jats:sup>C\u2010<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content> spectra of the compounds C=O were seen at 161.72\u2013169.27 ppm. Interestingly, compounds <jats:bold>3o<\/jats:bold>,<jats:bold> 3p<\/jats:bold> and <jats:bold>3r<\/jats:bold> significantly shortened immobility time in the The forced swimming test (FST) and The tail suspension test (TST) at 50 mg\/kg dose levels. In addition, compound <jats:bold>3r<\/jats:bold> exhibited higher levels of efficacy than the reference standard fluoxetine but had no effect on locomotor activity in the open\u2010field test. Compound <jats:bold>3r<\/jats:bold> significantly increased serotonin and norepinephrine and the metabolite 5\u2010hydroxyindoleacetic acid in mouse brain, suggesting that the effects of compound <jats:bold>3r<\/jats:bold> may be mediated through these neurotransmitters. In the seizure screen, 15 compounds showed some degree against <jats:styled-content style=\"fixed-case\">PTZ<\/jats:styled-content>\u2010induced seizure at a dose of 100 mg\/kg, and the tested compounds did not show any neurotoxicity at a dose of 300 mg\/kg in the rotarod test.<\/jats:p>","DOI":"10.1111\/cbdd.12668","type":"journal-article","created":{"date-parts":[[2015,9,22]],"date-time":"2015-09-22T08:21:42Z","timestamp":1442910102000},"page":"342-351","source":"Crossref","is-referenced-by-count":15,"title":["Practical Synthesis, Antidepressant, and Anticonvulsant Activity of 3\u2010Phenyliminoindolin\u20102\u2010one Derivatives"],"prefix":"10.1111","volume":"87","author":[{"given":"Jian\u2010Yin","family":"Ma","sequence":"first","affiliation":[{"name":"Food and Pharmacy College Zhejiang Ocean University and Zhejiang Provincial Engineering Technology Research Center of Marine Biomedical Products Zhoushan Zhejiang 316022 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