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Hence, three novel water soluble platinum complexes, [Pt(phen)(R\u2010gly)]<jats:styled-content style=\"fixed-case\">NO<\/jats:styled-content><jats:sub>3<\/jats:sub> (where phen is 1,10\u2010phenanthroline, R\u2010gly is methyl, amyl, and isopentyl\u2010glycine), have been synthesized and characterized by spectroscopic methods, conductivity measurements, and chemical analysis. The anticancer activities of synthesized complexes were investigated against human breast cancer cell line of <jats:styled-content style=\"fixed-case\">MDA<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">MB<\/jats:styled-content> 231. The 50% cytotoxic concentration values were determined to be 42.5, 58, and 70 <jats:italic>\u03bc<\/jats:italic><jats:sc>m<\/jats:sc> for methyl\u2010, amyl\u2010, and isopentyl\u2010gly complexes, respectively. These complexes were interacted with calf thymus <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> (ct\u2010<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>) via positive cooperative interaction. The modes of binding of the complexes to <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> were investigated by fluorescence spectroscopy and circular dichroism in combination with a molecular docking study. The result indicates that complexes with small or branched hydrocarbon chains can intercalate with <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content>. This is while amyl complexes with linear chains interacted additionally via groove binding. The results of the negative value of Gibbs energy for binding of isopentyl\u2010platinum to <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> and those of the molecular docking were coherent. Furthermore, the docking results demonstrated that hydrophobic interaction plays an important role in the complex\u2013<jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> interaction.<\/jats:p>","DOI":"10.1111\/cbdd.12735","type":"journal-article","created":{"date-parts":[[2016,2,2]],"date-time":"2016-02-02T08:41:26Z","timestamp":1454402486000},"page":"76-87","source":"Crossref","is-referenced-by-count":34,"title":["Structure Effect of Some New Anticancer Pt(<scp>II<\/scp>) Complexes of Amino Acid Derivatives with Small Branched or Linear Hydrocarbon Chains on Their <scp>DNA<\/scp> Interaction"],"prefix":"10.1111","volume":"88","author":[{"given":"Mahshid","family":"Kantoury","sequence":"first","affiliation":[{"name":"Chemistry &amp; Chemical Engineering Research Center of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahboube","family":"Eslami Moghadam","sequence":"additional","affiliation":[{"name":"Chemistry &amp; Chemical Engineering Research Center of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Akbar","family":"Tarlani","sequence":"additional","affiliation":[{"name":"Chemistry &amp; Chemical Engineering Research Center of Iran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adeleh","family":"Divsalar","sequence":"additional","affiliation":[{"name":"Department of Biological Sciences Kharazmi University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,5,19]]},"reference":[{"key":"e_1_2_6_2_1","unstructured":"DennyB.(1995) Cancer Research Laboratory and Heather Wansbrough and based on: Denny William A.; New Directions in Cancer Chemotherapy; Chemistry in New Zealand"},{"key":"e_1_2_6_3_1","first-page":"1","article-title":"The design and development of anti\u2010cancer drugs","author":"Denny B.","year":"1995","journal-title":"XII Biotech J Cancer Drugs"},{"key":"e_1_2_6_4_1","first-page":"107","article-title":"Synthesis, characterization and antibacterial activity of imidazole derivatives of 1, 10\u2010phenanthroline and their Cu (II), Co (II) and Ni (II) complexes","volume":"66","author":"Gomleksiz M.","year":"2013","journal-title":"S Afr J Chem"},{"key":"e_1_2_6_5_1","first-page":"245","article-title":"Metal\u2010based drug\u2010DNA interactions","volume":"57","author":"Garc\u00eda\u2010Ramos J.C.","year":"2013","journal-title":"J Mex Chem Soc"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.08.021"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1040-8428(01)00219-0"},{"key":"e_1_2_6_8_1","first-page":"38","article-title":"Transition metal complexes as potential therapeutic agents","volume":"5","author":"Rafique S.","year":"2010","journal-title":"Biotechnol Mol Biol Rev"},{"key":"e_1_2_6_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jorganchem.2007.03.019"},{"key":"e_1_2_6_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1734-1140(12)70726-0"},{"key":"e_1_2_6_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.inoche.2014.05.032"},{"key":"e_1_2_6_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jinorgbio.2007.04.009"},{"key":"e_1_2_6_13_1","first-page":"330","article-title":"Synthesis, characterization, DNA\u2010binding and spectral properties of complexes [Ru (L) 4 (dppz)] 2 + (L= Im and MeIm)","volume":"102","author":"Chen L.M.","year":"2008","journal-title":"J Chem Pharm Res"},{"key":"e_1_2_6_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF03246535"},{"key":"e_1_2_6_15_1","first-page":"811","article-title":"DNA\u2010binding studies of some potential antitumor 2, 2\u2032\u2013bipyridine Pt (II)\/Pd (II) complexes of piperidinedithiocarbamate. 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