{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T18:55:30Z","timestamp":1777143330413,"version":"3.51.4"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2016,3,24]],"date-time":"2016-03-24T00:00:00Z","timestamp":1458777600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2016,8]]},"abstract":"<jats:p>Recent studies showed that Guaiazulene (GA) and Sodium guaiazulene sulfonate (GAS\u2010Na) have good anti\u2010gastric ulcer effect. Here, two series of GA derivatives were synthesized and evaluated for their anti\u2010gastric ulcer activity. The data obtained from <jats:italic>in vivo<\/jats:italic> testing of these compounds in a rodent ethanol\u2010induced stomach injury model are discussed. Among the tested compounds, <jats:bold>A1<\/jats:bold>,<jats:bold> A4<\/jats:bold>, and <jats:bold>A9<\/jats:bold> (ulcer index: 1.125 \u00b1 1.246**, 1.714 \u00b1 0.756*, 1.875 \u00b1 1.126*) exhibited better anti\u2010gastric ulcer activity than the positive control Omeprazole (2.005 \u00b1 1.011*). The information got from these studies and the results of 3D\u2010SAR investigation may be useful in the design of novel anti\u2010gastric ulcer agents.<\/jats:p>","DOI":"10.1111\/cbdd.12753","type":"journal-article","created":{"date-parts":[[2016,3,3]],"date-time":"2016-03-03T15:57:38Z","timestamp":1457020658000},"page":"264-271","source":"Crossref","is-referenced-by-count":15,"title":["Synthesis and Biological Evaluation of 3, 8\u2010dimethyl\u20105\u2010isopropylazulene Derivatives as Anti\u2010gastric Ulcer Agent"],"prefix":"10.1111","volume":"88","author":[{"given":"Tingting","family":"Cao","sequence":"first","affiliation":[{"name":"College of Chemistry Sichuan University 29 Wangjiang Road Chengdu 610064 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry Sichuan University 29 Wangjiang Road Chengdu 610064 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziyao","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Environment Protection Engineering Southwest University for Nationalities Section 4, Southern First Ring Road Chengdu 610041 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mingxing","family":"Yuan","sequence":"additional","affiliation":[{"name":"College of Chemistry Sichuan University 29 Wangjiang Road Chengdu 610064 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Li","sequence":"additional","affiliation":[{"name":"College of Chemistry Sichuan University 29 Wangjiang Road Chengdu 610064 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Environment Protection Engineering Southwest University for Nationalities Section 4, Southern First Ring Road Chengdu 610041 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchuan","family":"Feng","sequence":"additional","affiliation":[{"name":"College of Chemistry &amp; Environment Protection Engineering Southwest University for Nationalities Section 4, Southern First Ring Road Chengdu 610041 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shufan","family":"Yin","sequence":"additional","affiliation":[{"name":"College of Chemistry Sichuan University 29 Wangjiang Road Chengdu 610064 Sichuan Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,3,24]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2006\/175217"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcna.2004.09.001"},{"key":"e_1_2_7_4_1","first-page":"95","article-title":"Gastric ulcers induced by systemic hypoxia","volume":"41","author":"Syam A.F.","year":"2009","journal-title":"Acta Med Indones"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf2003267"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.08.018"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0939-6411(03)00100-0"},{"key":"e_1_2_7_8_1","first-page":"3667","article-title":"Effect of sodium gualenate on experimental gastritis in rats","volume":"15","author":"Ueda F.","year":"1987","journal-title":"Jpn Pharmacol Ther"},{"key":"e_1_2_7_9_1","first-page":"1086","article-title":"Biochemische untersuchungen von kamillen\u2010inhaltsstoffen","volume":"22","author":"Thiemer V.K.","year":"1972","journal-title":"Arzneimittelforschung"},{"key":"e_1_2_7_10_1","first-page":"1303","article-title":"Studies on anti\u2010inflammatory activity of sodium guaiazulene\u20103\u2010sulfonate","volume":"14","author":"Shibata Y.","year":"1986","journal-title":"Jpn Pharmacol Ther"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.8.329"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1248\/bpb1978.8.337"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02358603"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4FO00381K"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.38.3355"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm000942e"}],"container-title":["Chemical Biology &amp; 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