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However, the clinical application of this nature compound had been hampered owing to its properties such as poor aqueous solubility, low gastrointestinal absorption, and reduced bioavailability. Therefore, we developed Janus magnetic mesoporous silica nanoparticles (Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">mSiO<\/jats:styled-content><jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s) consisting of a Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub> head for magnetic targeting and a mesoporous SiO<jats:sub>2<\/jats:sub> body for berberine delivery. A <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010sensitive group was introduced on the surface of mesoporous silica for berberine loading to develop a tumor microenvironment\u2010responsive nanocarrier, which exhibited uniform morphology, good superparamagnetic properties, high drug\u2010loading amounts, superior endocytic ability, and low cytotoxicity. Berberine\u2010loaded Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">mSiO<\/jats:styled-content><jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s exerted extraordinarily high specificity for hepatocellular carcinoma cells, which was due to the <jats:styled-content style=\"fixed-case\">pH<\/jats:styled-content>\u2010responsive berberine release, as well as higher endocytosis capacity in hepatocellular carcinoma cells rather than normal liver cells. More importantly, an external magnetic field could significantly improve antitumor activity of Ber\u2010loaded Fe<jats:sub>3<\/jats:sub>O<jats:sub>4<\/jats:sub>\u2010<jats:styled-content style=\"fixed-case\">mSiO<\/jats:styled-content><jats:sub>2<\/jats:sub> <jats:styled-content style=\"fixed-case\">NP<\/jats:styled-content>s through enhancing berberine internalization. Taken together, our results suggest that Janus nanocarriers driven by the magnetic field may provide an effective and safe way to facilitate clinical use of berberine against hepatocellular carcinoma.<\/jats:p>","DOI":"10.1111\/cbdd.12866","type":"journal-article","created":{"date-parts":[[2016,9,12]],"date-time":"2016-09-12T16:17:13Z","timestamp":1473697033000},"page":"464-469","source":"Crossref","is-referenced-by-count":56,"title":["Berberine\u2010loaded Janus nanocarriers for magnetic field\u2010enhanced therapy against hepatocellular carcinoma"],"prefix":"10.1111","volume":"89","author":[{"given":"Zheng","family":"Wang","sequence":"first","affiliation":[{"name":"CAS Key Laboratory of Bio\u2010Medical Diagnostics Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences  Suzhou China"},{"name":"University of Chinese Academy of Sciences  Beijing 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