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The ammonium salts of the carboxylic acids are found to be not active, while anionic [Ph<jats:sub>3<\/jats:sub>SnCl(L)]<jats:sup>\u2212<\/jats:sup> exhibited high cytotoxicity in <jats:styled-content style=\"fixed-case\">nM<\/jats:styled-content> range, both higher activity and selectivity than cisplatin. Compounds <jats:bold>1<\/jats:bold> and <jats:bold>2<\/jats:bold> are inducing apoptosis, which was proved with the morphological and biochemical features such as membrane blebbing, translocation of phosphatidylserine, and <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> fragmentation. Thus, accumulation of cells in sub\u2010G1 phase is observed. Both anionic organotin(<jats:styled-content style=\"fixed-case\">IV<\/jats:styled-content>) compounds showed potent cytotoxic and apoptotic properties against five cancer cell lines of various histogenetic origin.<\/jats:p>","DOI":"10.1111\/cbdd.12885","type":"journal-article","created":{"date-parts":[[2016,10,17]],"date-time":"2016-10-17T08:32:43Z","timestamp":1476693163000},"page":"628-633","source":"Crossref","is-referenced-by-count":8,"title":["Anionic chlorido(triphenyl)tin(<scp>IV<\/scp>) bearing <i>N<\/i>\u2010phthaloylglycinato or 1,2,4\u2010benzenetricarboxylato 1,2\u2010anhydride ligands: potential cytotoxic and apoptosis\u2010inducing agents against several types of cancer"],"prefix":"10.1111","volume":"89","author":[{"given":"Denise","family":"H\u00fcbner","sequence":"first","affiliation":[{"name":"Institute of Virology University of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Milena R.","family":"Kalu\u0111erovi\u0107","sequence":"additional","affiliation":[{"name":"Department of Oral, Maxillary, Facial and Reconstructive Plastic Surgery University Hospital of Leipzig  Leipzig Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"G\u00f3mez\u2010Ruiz","sequence":"additional","affiliation":[{"name":"Departamento de Biolog\u00eda y Geolog\u00eda F\u00edsica y Qu\u00edmica Inorg\u00e1nica E.S.C.E.T. 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