{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,17]],"date-time":"2026-03-17T04:46:14Z","timestamp":1773722774084,"version":"3.50.1"},"reference-count":14,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T00:00:00Z","timestamp":1480636800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2017,5]]},"abstract":"<jats:p>In this study, drug target was identified using <jats:styled-content style=\"fixed-case\">KEGG<\/jats:styled-content> database and network analysis through Cytoscape software. Designed series of novel benzimidazoles were taken along with reference standard Flibanserin for <jats:italic>insilico<\/jats:italic> modeling. The novel 4\u2010(1<jats:italic>H<\/jats:italic>\u2010benzo[<jats:italic>d<\/jats:italic>]imidazol\u20102\u2010yl)\u2010<jats:italic>N<\/jats:italic>\u2010(substituted phenyl)\u20104\u2010oxobutanamide (<jats:bold>3a\u2013j<\/jats:bold>) analogs were synthesized and evaluated for their antidepressant activity. Reaction of 4\u2010(1<jats:italic>H<\/jats:italic>\u2010benzo[<jats:italic>d<\/jats:italic>]imidazol\u20102\u2010yl)\u20104\u2010oxobutanoic acid (<jats:bold>1<\/jats:bold>) with 4\u2010(1<jats:italic>H<\/jats:italic>\u2010benzo [<jats:italic>d<\/jats:italic>] imidazol\u20102\u2010yl)\u20104\u2010oxobutanoyl chloride (<jats:bold>2<\/jats:bold>) furnished novel 4\u2010(1<jats:italic>H<\/jats:italic>\u2010benzo [<jats:italic>d<\/jats:italic>] imidazol\u20102\u2010yl)\u2010<jats:italic>N<\/jats:italic>\u2010(substituted phenyl)\u20104\u2010oxobutanamide (<jats:bold>3a\u2013j<\/jats:bold>). All the newly synthesized compounds were characterized by <jats:styled-content style=\"fixed-case\">IR<\/jats:styled-content>, <jats:sup>1<\/jats:sup>H\u2010<jats:styled-content style=\"fixed-case\">NMR<\/jats:styled-content>, and mass spectral analysis. The antidepressant activities of synthesized derivatives were compared with standard drug clomipramine at a dose level of 20\u00a0mg\/kg. Among the derivatives tested, most of the compounds were found to have potent activity against depression. The high level of activity was shown by the compounds <jats:bold>3d<\/jats:bold>,<jats:bold> 3e<\/jats:bold>,<jats:bold> 3i,<\/jats:bold> and it significantly reduced the duration of immobility time at the dose level of 50\u00a0mg\/kg.<\/jats:p>","DOI":"10.1111\/cbdd.12894","type":"journal-article","created":{"date-parts":[[2016,12,2]],"date-time":"2016-12-02T07:44:04Z","timestamp":1480664644000},"page":"714-722","source":"Crossref","is-referenced-by-count":13,"title":["Graph theoretical analysis, <i>insilico<\/i> modeling, design, and synthesis of compounds containing benzimidazole skeleton as antidepressant agents"],"prefix":"10.1111","volume":"89","author":[{"given":"Panneerselvam","family":"Theivendren","sequence":"first","affiliation":[{"name":"International Research Centre Kalasalingam University  Krishnankoil Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arumugam","family":"Subramanian","sequence":"additional","affiliation":[{"name":"National Centre for Advanced Research in Discrete Mathematics Kalasalingam University  Krishnankoil Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Indhumathy","family":"Murugan","sequence":"additional","affiliation":[{"name":"National Centre for Advanced Research in Discrete Mathematics Kalasalingam University  Krishnankoil Tamilnadu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shrinivas D.","family":"Joshi","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry \u201cSET's\u201d College of Pharmacy  Dharwad Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uttam A.","family":"More","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry \u201cSET's\u201d College of Pharmacy  Dharwad Karnataka India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,12,2]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.physbeh.2013.10.026"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-010-9533-9"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.catcom.2006.10.022"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.200590334"},{"key":"e_1_2_7_6_1","first-page":"1145","volume":"28","author":"Naithani P.","year":"1990","journal-title":"Indian J. 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