{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T00:14:26Z","timestamp":1778717666755,"version":"3.51.4"},"reference-count":13,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2017,1,27]],"date-time":"2017-01-27T00:00:00Z","timestamp":1485475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001332","name":"Council for Scientific and Industrial Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001332","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2017,6]]},"abstract":"<jats:p>A series of novel bisquinoline compounds comprising <jats:italic>N<\/jats:italic><jats:sup>1<\/jats:sup>\u2010(7\u2010chloroquinolin\u20104\u2010yl) ethane\u20101,2\u2010diamine and 7\u2010chloro\u2010<jats:italic>N<\/jats:italic>\u2010(2\u2010(piperazin\u20101\u2010yl)ethyl)quinolin\u20104\u2010amine connected with 7\u2010chloro\u20104\u2010aminoquinoline containing various amino acids is described. We have bio\u2010evaluated the compounds against both chloroquine\u2010sensitive (3D7) and chloroquine\u2010resistant (K1) strains of <jats:italic>Plasmodium falciparum<\/jats:italic> in vitro. Among the series, compounds <jats:bold>4<\/jats:bold> and <jats:bold>7<\/jats:bold> exhibited 1.8\u2010 and 10.6\u2010fold superior activity as compared to chloroquine (CQ; IC<jats:sub>50<\/jats:sub>\u00a0=\u00a00.255\u00a0\u00b1\u00a00.049\u00a0\u03bc<jats:sc>m<\/jats:sc>) against the K1 strain with IC<jats:sub>50<\/jats:sub> values 0.137\u00a0\u00b1\u00a00.014 and 0.026\u00a0\u00b1\u00a00.007\u00a0\u03bc<jats:sc>m<\/jats:sc>, respectively. Furthermore, compound <jats:bold>7<\/jats:bold> also displayed promising activity against the 3D7 strain (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a00.024\u00a0\u00b1\u00a00.003\u00a0\u03bc<jats:sc>m<\/jats:sc>) of <jats:italic>P.\u00a0falciparum<\/jats:italic> when compared to CQ. All the compounds in the series displayed resistance factor between 0.57 and 4.71 as against 51 for CQ. These results suggest that bisquinolines can be explored for further development as new antimalarial agents active against chloroquine\u2010resistant <jats:italic>P.\u00a0falciparum<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/cbdd.12914","type":"journal-article","created":{"date-parts":[[2016,11,29]],"date-time":"2016-11-29T08:47:48Z","timestamp":1480409268000},"page":"901-906","source":"Crossref","is-referenced-by-count":17,"title":["Design, synthesis and in vitro antiplasmodial activity of some bisquinolines against chloroquine\u2010resistant strain"],"prefix":"10.1111","volume":"89","author":[{"given":"Srinivasarao","family":"Kondaparla","sequence":"first","affiliation":[{"name":"Medicinal &amp; Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pooja","family":"Agarwal","sequence":"additional","affiliation":[{"name":"Parasitology Division CSIR\u2010Central Drug Research Institute  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumkum","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Parasitology Division CSIR\u2010Central Drug Research Institute  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil K.","family":"Puri","sequence":"additional","affiliation":[{"name":"Parasitology Division CSIR\u2010Central Drug Research Institute  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seturam B.","family":"Katti","sequence":"additional","affiliation":[{"name":"Medicinal &amp; Process Chemistry Division CSIR\u2010Central Drug Research Institute  Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm0310840"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm4006077"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm990946n"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(01)00383-3"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00306-1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1071\/C97086"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm9803828"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00001a026"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm001096a"},{"key":"e_1_2_7_11_1","first-page":"81","volume":"39","author":"Tomar N.","year":"2013","journal-title":"Acta Ciencia Indica Chem."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.05.024"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-016-1555-5"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.2174\/1385272043369773"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.12914","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.12914","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,3]],"date-time":"2023-10-03T16:59:43Z","timestamp":1696352383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.12914"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,1,27]]},"references-count":13,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2017,6]]}},"alternative-id":["10.1111\/cbdd.12914"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.12914","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,1,27]]}}}