{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,5]],"date-time":"2025-12-05T12:14:38Z","timestamp":1764936878828,"version":"3.37.3"},"reference-count":33,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2017,4,11]],"date-time":"2017-04-11T00:00:00Z","timestamp":1491868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003453","name":"Natural Science Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2014A020212484"],"award-info":[{"award-number":["2014A020212484"]}],"id":[{"id":"10.13039\/501100003453","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81370555"],"award-info":[{"award-number":["81370555"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2017,9]]},"abstract":"<jats:p>The expression pattern and biological role of long non\u2010coding <jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> (lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content>) in cancer has been reported to be involved in many cancers. Here, we report the expression and biological role of a newly discovered lnc<jats:styled-content style=\"fixed-case\">RNA<\/jats:styled-content> NmrA\u2010like family domain containing 1 pseudogene (Loc344887) in gallbladder cancer (<jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content>). In this study, we found that the expression of Loc344887 was significantly elevated in <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> tissues and cell lines when compared with matched normal tissues and normal epithelial bile duct cell line, respectively. High Loc344887 was associated with larger tumor size. Loc344887 was upregulated significantly after ectopic expression of nuclear factor (erythroid\u2010derived 2)\u2010like 2 (Nrf2) in <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> cells. Downregulation of Loc344887 in <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content> cells suppressed cell proliferation, blocked cells in G0\/S phase, and decreased the migration and invasion cell numbers. In addition, downregulation of Loc344887 decreased the expression of transcription factor Twist, mesenchymal marker Vimentin, and N\u2010cadherin and increased the expression of epithelial maker E\u2010cadherin, which could prompt a mesenchymal\u2010to\u2010epithelial transition phenotype. These results demonstrated that Loc344887 might contribute to cell proliferation and epithelial\u2010to\u2010mesenchymal transition process in <jats:styled-content style=\"fixed-case\">GBC<\/jats:styled-content>, which might be a potential therapeutic target.<\/jats:p>","DOI":"10.1111\/cbdd.12967","type":"journal-article","created":{"date-parts":[[2017,2,28]],"date-time":"2017-02-28T16:06:44Z","timestamp":1488298004000},"page":"456-463","source":"Crossref","is-referenced-by-count":26,"title":["The NmrA\u2010like family domain containing 1 pseudogene Loc344887 is amplified in gallbladder cancer and promotes epithelial\u2013mesenchymal transition"],"prefix":"10.1111","volume":"90","author":[{"given":"Xiao\u2010Cai","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"},{"name":"Tertiary Referral Center for Abdominal Surgery Department of General Surgery Shanghai Tenth People's Hospital Affiliated to Tongji University  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shou\u2010hua","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hong\u2010hui","family":"Ou","sequence":"additional","affiliation":[{"name":"Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bing","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery The First Affiliated Hospital of Bengbu Medical College  Bengbu Anhui Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of General Surgery The First Affiliated Hospital of Anhui Medical University  Hefei Anhui Province China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Bio\u2010Theraphy Center The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2101-6680","authenticated-orcid":false,"given":"Hua","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hepatic Surgery The Third Affiliated Hospital of Sun Yat\u2010sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,4,11]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1479-666X(08)80073-X"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2009-0302"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2014.343"},{"key":"e_1_2_7_5_1","first-page":"949","volume":"16","author":"Saito S.","year":"2006","journal-title":"Oncol. 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