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At present, there is limited understanding of the infectious mechanism, and no approved therapy has been reported. Despite the withdrawal of public health emergency, the WHO still considers the ZIKV as a highly significant and long\u2010term public health challenge that the situation has to be addressed rapidly. Non\u2010structural protein 5 is essential for capping and replication of viral RNA and comprises a methyltransferase and RNA\u2010dependent RNA polymerase (RdRp) domain. We used molecular modeling to obtain the structure of ZIKV RdRp, and by molecular docking and phylogeny analysis, we here demonstrate the potential sites for drug screening. Two metal binding sites and an NS3\u2010interacting region in ZIKV RdRp are demonstrated as potential drug screening sites. The docked structures reveal a remarkable degree of conservation at the substrate binding site and the potential drug screening sites. A phylogeny\u2010based approach is provided for an emergency preparedness, where similar class of ligands could target phylogenetically related proteins.<\/jats:p>","DOI":"10.1111\/cbdd.13054","type":"journal-article","created":{"date-parts":[[2017,6,21]],"date-time":"2017-06-21T17:02:42Z","timestamp":1498064562000},"page":"322-327","source":"Crossref","is-referenced-by-count":3,"title":["RNA\u2010dependent RNA polymerase: Addressing Zika outbreak by a phylogeny\u2010based drug target study"],"prefix":"10.1111","volume":"91","author":[{"given":"Preyesh","family":"Stephen","sequence":"first","affiliation":[{"name":"Laboratory of Molecular Endocrinology CHU Research Center Laval University Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9149-375X","authenticated-orcid":false,"given":"Sheng\u2010Xiang","family":"Lin","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Endocrinology CHU Research Center Laval University Qu\u00e9bec Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,7,29]]},"reference":[{"key":"e_1_2_2_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20556"},{"key":"e_1_2_2_3_1","doi-asserted-by":"crossref","first-page":"1198","DOI":"10.1093\/cid\/ciw476","volume":"63","author":"Sharp T. 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