{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:09:58Z","timestamp":1790262598855,"version":"4.1.0"},"reference-count":39,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2017,8,31]],"date-time":"2017-08-31T00:00:00Z","timestamp":1504137600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21501044"],"award-info":[{"award-number":["21501044"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2018,1]]},"abstract":"<jats:p>\n                    The modified quantum dots (\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s) have been used in intracellular probing and drug delivery because of their special chemical and physical properties. In this paper, two \u03b2\u2010cyclodextrin (\u03b2\u2010\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    )\u2010modified CdSe\/ZnS\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s with strong optical emission properties were synthesized as drug carriers to induce apoptosis. The positively charged\n                    <jats:sc>l<\/jats:sc>\n                    \u2010Arginine (\n                    <jats:sc>l<\/jats:sc>\n                    \u2010Arg) and neutral\n                    <jats:sc>l<\/jats:sc>\n                    \u2010Tryptophan (\n                    <jats:sc>l<\/jats:sc>\n                    \u2010Trp) were selected as ligands to compare the effect of charge on bioactivity of\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s nanoparticles. The in vitro assays revealed that these modified\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s showed good Dox carrier ability and significantly high inhibition rate to cancer cells. Especially, the more positively charged \u03b2\u2010\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    \u2010\n                    <jats:sc>l<\/jats:sc>\n                    \u2010Arg\u2010polyamine\u2010coated CdSe\/ZnS\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s could effectively deliver the doxorubicin (Dox) into cells and exhibit excellent cell selectivity in cancer versus normal cells. The Dox\u2010loaded\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s could enter intracellular, which showed that the Dox can efficiently go through the membranes at the existence of \u03b2\u2010\n                    <jats:styled-content style=\"fixed-case\">CD<\/jats:styled-content>\n                    . Several lines of evidence suggest that the Dox\u2010loaded\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s can efficiently induce apoptosis likely related to the production of\n                    <jats:styled-content style=\"fixed-case\">ROS<\/jats:styled-content>\n                    . We expect that the modified\n                    <jats:styled-content style=\"fixed-case\">QD<\/jats:styled-content>\n                    s can enhance the amount of hydrophobic antitumor drugs in cells and can also be used as fluorescent imaging agents.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.13080","type":"journal-article","created":{"date-parts":[[2017,8,9]],"date-time":"2017-08-09T03:54:59Z","timestamp":1502250899000},"page":"285-293","source":"Crossref","is-referenced-by-count":20,"title":["The delivery of doxorubicin of multifunctional \u03b2\u2010cyclodextrin\u2010modified CdSe\/ZnS quantum dots for bioactivity and nano\u2010probing"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2635-788X","authenticated-orcid":false,"given":"Mei\u2010Xia","family":"Zhao","sequence":"first","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering of Henan Province Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bing\u2010Jie","family":"Zhu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering of Henan Province Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen\u2010Jing","family":"Yao","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering of Henan Province Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di\u2010Feng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering of Henan Province Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaojie","family":"Wang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Natural Medicine and Immune Engineering of Henan Province Henan University  Kaifeng China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,8,31]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2015.1071791"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5CS00331H"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12268"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5NR06697B"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S39658"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b09777"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2011.09.011"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1117\/1.JBO.20.11.110504"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1039\/c3cs60017c"},{"key":"e_1_2_7_11_1","first-page":"1323","volume":"9","author":"Rizvi S. B.","year":"2014","journal-title":"Int. J. Nanomed."},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5SC00020C"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2015.11.006"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20206a"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2015.08.004"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nantod.2014.06.005"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn300415x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1039\/b915139g"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CC02918F"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4NR03058C"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.3109\/1061186X.2010.526227"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmat4526"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.chemmater.5b03614"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5RA24811F"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nprot.2015.050"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4CS00124A"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.201502868"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2015.05.008"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12052"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1039\/C4BM00417E"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sc20187a"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1039\/b926512k"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm051602q"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/cm8009176"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja003633m"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/bc400015r"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.04.034"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2016.02.020"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2015.07.049"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bab.1071"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.13080","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.13080","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,29]],"date-time":"2023-09-29T06:19:24Z","timestamp":1695968364000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.13080"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,8,31]]},"references-count":39,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,1]]}},"alternative-id":["10.1111\/cbdd.13080"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.13080","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,8,31]]}}}