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Therefore, no definite treatments exist for SWS and treatment options only mitigate the intensity of its clinical manifestations. Biological assay design for drug discovery against this syndrome demands comprehensive knowledge on mechanisms which are involved in its pathogenesis. By analysis of the interrelated molecular targets of SWS, some in vitro bioassay systems can be allotted for drug screening against its progression. Development of such platforms of bioassay can bring along the implementation of high\u2010throughput screening of natural or synthetic compounds in drug discovery programs. Regarding the fact that study of molecular targets and their integration in biological assay design can facilitate the process of effective drug discovery; some potential biological targets and their respective biological assay for SWS drug discovery are propounded in this review. For this purpose, some biological targets for SWS drug discovery such as acetylcholinesterase, alkaline phosphatase, GABAergic receptors, Hypoxia\u2010Inducible Factor (HIF)\u20101\u03b1 and 2\u03b1 are suggested.<\/jats:p>","DOI":"10.1111\/cbdd.13112","type":"journal-article","created":{"date-parts":[[2017,9,21]],"date-time":"2017-09-21T14:12:40Z","timestamp":1506003160000},"page":"359-369","source":"Crossref","is-referenced-by-count":2,"title":["Potential biological targets for bioassay development in drug discovery of Sturge\u2013Weber syndrome"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0286-5342","authenticated-orcid":false,"given":"Fatemeh","family":"Mohammadipanah","sequence":"first","affiliation":[{"name":"Department of Microbial Biotechnology School of Biology and Center of Excellence in Phylogeny of Living Organisms College of Science University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fatemeh","family":"Salimi","sequence":"additional","affiliation":[{"name":"Department of Microbial Biotechnology School of Biology and Center of Excellence in Phylogeny of Living Organisms College of Science University of Tehran Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2017,10,11]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-409-90018-7.50045-1"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-62702-5.00011-1"},{"key":"e_1_2_11_4_1","first-page":"1","volume-title":"Sturge\u2010Weber Syndrome","author":"Bodensteiner J. 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