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Vm\n CT<\/jats:styled-content>\n 1 (Phe\u2013Leu\u2013Gly\u2013Ala\u2013Leu\u2013Trp\u2013Asn\u2013Val\u2013Ala\u2013Lys\u2013Ser\u2013Val\u2013Phe\u2013\n NH<\/jats:styled-content>\n 2<\/jats:sub>\n ) is an \u03b1\u2010helical antimicrobial peptide that was obtained from the\n Vaejovis mexicanus smithi<\/jats:italic>\n scorpion venom. Some of its analogs showed to be as antimicrobial as the wild type, and they were designed for understanding the influence of physiochemical parameters on antimicrobial and hemolytic activity. Some cationic antimicrobial peptides exhibit anticancer activity so Vm\n CT<\/jats:styled-content>\n 1 analogs were tested to verify the anticancer activity of this family of peptides. The analogs were synthesized, purified, characterized, and the conformational studies were performed. The anticancer activity was assessed against\n MCF<\/jats:styled-content>\n \u20107 mammary cancer cells. The results indicated that [Glu]\n 7<\/jats:sup>\n \u2010Vm\n CT<\/jats:styled-content>\n 1\u2010\n NH<\/jats:styled-content>\n 2<\/jats:sub>\n , [Lys]\n 3<\/jats:sup>\n \u2010Vm\n CT<\/jats:styled-content>\n 1\u2010\n NH<\/jats:styled-content>\n 2<\/jats:sub>\n , and [Lys]\n 7<\/jats:sup>\n \u2010Vm\n CT<\/jats:styled-content>\n 1\u2010\n NH<\/jats:styled-content>\n 2<\/jats:sub>\n analogs presented moderated helical tendency (0.23\u20130.61) and tendency of anticancer activity at 25\u00a0\u03bcmol\/L in 24\u00a0hr of experiment; and [Trp]\n 9<\/jats:sup>\n \u2010Vm\n CT<\/jats:styled-content>\n 1\u2010\n NH<\/jats:styled-content>\n 2<\/jats:sub>\n analog that presented low helical tendency and moderated anticancer activity at 50\u00a0\u03bcmol\/L. These results demonstrated that single substitutions on Vm\n CT<\/jats:styled-content>\n 1 led to different physicochemical features and could assist on the understanding of anticancer activity of this peptide family.\n <\/jats:p>","DOI":"10.1111\/cbdd.13123","type":"journal-article","created":{"date-parts":[[2017,10,17]],"date-time":"2017-10-17T10:16:55Z","timestamp":1508235415000},"page":"588-596","source":"Crossref","is-referenced-by-count":23,"title":["Anticancer activity of VmCT1 analogs against MCF\u20107 cells"],"prefix":"10.1111","volume":"91","author":[{"given":"Cibele Nicolaski","family":"Pedron","sequence":"first","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gislaine Patricia","family":"Andrade","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roseli Hiromi","family":"Sato","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6165-9138","authenticated-orcid":false,"given":"Marcelo Der Torossian","family":"Torres","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giselle","family":"Cerchiaro","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anderson Orzari","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9420-0956","authenticated-orcid":false,"suffix":"Jr.","given":"Vani Xavier","family":"Oliveira","sequence":"additional","affiliation":[{"name":"Centro de Ci\u00eancias Naturais e Humanas Universidade Federal do ABC Santo Andr\u00e9 SP Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,11,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/675391"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.2174\/0929867321666140217110155"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1021\/bm201098j"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5b04547"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2017.00005"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2016.00194"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/slct.201601590"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/psc.2641"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12354"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2013.00294"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0126390"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557514666141107120954"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.02.002"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2016.11.040"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-3011.1990.tb00939.x"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0003-2697(70)90146-6"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2014.01.024"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2015.00144"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.5472"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1063\/1.1731802"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-012-0302-9"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2007.11.008"},{"key":"e_1_2_8_24_1","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3993\/jfbi03201503","volume":"8","author":"Liu X.","year":"2015","journal-title":"J. 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