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The compounds inhibited <jats:styled-content style=\"fixed-case\">AC<\/jats:styled-content>hE with <jats:italic>K<\/jats:italic><jats:sub><jats:italic>i<\/jats:italic><\/jats:sub> in the range of 22.7\u00a0\u00b1\u00a010.3\u2010109.1\u00a0\u00b1\u00a027.0\u00a0n<jats:sc>m<\/jats:sc>, whereas the tacrine had <jats:italic>K<\/jats:italic><jats:sub><jats:italic>i<\/jats:italic><\/jats:sub> value of 66.5\u00a0\u00b1\u00a013.8\u00a0n<jats:sc>m<\/jats:sc>. Electronic structure calculations at M06\u2010L\/6\u201031\u00a0+\u00a0G(d,p)\/\/<jats:styled-content style=\"fixed-case\">AM<\/jats:styled-content>1 level and molecular docking studies were also performed to enlighten inhibition mechanism and to support experimental findings. Results obtained from calculations of molecular properties showed that the compounds obey drug\u2010likeness properties. The experimental and computational findings obtained in this study might be useful in the design of novel inhibitors against <jats:styled-content style=\"fixed-case\">hCA<\/jats:styled-content> I, <jats:styled-content style=\"fixed-case\">hCA<\/jats:styled-content> II, and AChE.<\/jats:p>","DOI":"10.1111\/cbdd.13149","type":"journal-article","created":{"date-parts":[[2017,11,16]],"date-time":"2017-11-16T07:02:37Z","timestamp":1510815757000},"page":"854-866","source":"Crossref","is-referenced-by-count":140,"title":["Synthesis, molecular modeling, and biological evaluation of 4\u2010[5\u2010aryl\u20103\u2010(thiophen\u20102\u2010yl)\u20104,5\u2010dihydro\u20101<i>H<\/i>\u2010pyrazol\u20101\u2010yl] benzenesulfonamides toward acetylcholinesterase, carbonic anhydrase I and <scp>II<\/scp> enzymes"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4833-7900","authenticated-orcid":false,"given":"Cem","family":"Yamali","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Halise Inci","family":"Gul","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdulilah","family":"Ece","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Chemistry Faculty of Pharmacy Biruni University  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Parham","family":"Taslimi","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilhami","family":"Gulcin","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science Ataturk University  Erzurum Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2017,12,4]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1","volume":"46","author":"Copeland R. 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