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Biological results showed antiparasitic activity with IC<jats:sub>50<\/jats:sub> values in the \u03bc<jats:sc>m<\/jats:sc> range. The in vitro cytotoxicity of these molecules was assessed by incubation with human HepG2 cells; for some derivatives, cytotoxicity was observed at significantly higher concentrations than antiparasitic activity. The 2,9\u2010bis[(substituted\u2010aminomethyl)phenyl]\u20101,10\u2010phenanthroline <jats:bold>1h<\/jats:bold> was identified as the most potent antimalarial candidate with ratios of cytotoxic\u2010to\u2010antiparasitic activities of 107 and 39 against a chloroquine\u2010sensitive and a chloroquine\u2010resistant strain of <jats:italic>P. falciparum<\/jats:italic>, respectively. As the telomeres of the parasite <jats:italic>P. falciparum<\/jats:italic> are the likely target of this compound, we investigated stabilization of the Plasmodium telomeric G\u2010quadruplexes by our phenanthroline derivatives through a FRET melting assay. The ligands <jats:bold>1f<\/jats:bold> and <jats:bold>1m<\/jats:bold> were noticed to be more specific for FPf8T with higher stabilization for FPf8T than for the human F21T sequence.<\/jats:p>","DOI":"10.1111\/cbdd.13164","type":"journal-article","created":{"date-parts":[[2017,12,20]],"date-time":"2017-12-20T16:09:39Z","timestamp":1513786179000},"page":"974-995","source":"Crossref","is-referenced-by-count":37,"title":["Design, synthesis, and antiprotozoal evaluation of new 2,9\u2010bis[(substituted\u2010aminomethyl)phenyl]\u20101,10\u2010phenanthroline derivatives"],"prefix":"10.1111","volume":"91","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8577-3894","authenticated-orcid":false,"given":"Jean","family":"Guillon","sequence":"first","affiliation":[{"name":"INSERM U1212 UMR CNRS 5320, ARNA Laboratory UFR des Sciences Pharmaceutiques Universit\u00e9 de Bordeaux  Bordeaux 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