{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T15:20:40Z","timestamp":1777908040737,"version":"3.51.4"},"reference-count":35,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2018,10,3]],"date-time":"2018-10-03T00:00:00Z","timestamp":1538524800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003200","name":"Kementerian Sains, Teknologi dan Inovasi","doi-asserted-by":"publisher","award":["02\u201001\u201003\u2010SF0937"],"award-info":[{"award-number":["02\u201001\u201003\u2010SF0937"]}],"id":[{"id":"10.13039\/501100003200","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/17"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/17"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003093","name":"Ministry of Higher Education, Malaysia","doi-asserted-by":"publisher","award":["UM.C\/625\/1\/HIR\/MOHE\/MED\/33"],"award-info":[{"award-number":["UM.C\/625\/1\/HIR\/MOHE\/MED\/33"]}],"id":[{"id":"10.13039\/501100003093","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2019,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Compounds with activity at serotonin (5\u2010hydroxytryptamine) 5\u2010HT<jats:sub>2<\/jats:sub> and \u03b1<jats:sub>1<\/jats:sub> adrenergic receptors have potential for the treatment of central nervous system disorders, drug addiction or overdose. Isolaureline, dicentrine and glaucine enantiomers were synthesized, and their in vitro functional activities at human 5\u2010HT<jats:sub>2<\/jats:sub> and adrenergic \u03b1<jats:sub>1<\/jats:sub> receptor subtypes were evaluated. The enantiomers of isolaureline and dicentrine acted as antagonists at 5\u2010HT<jats:sub>2<\/jats:sub> and \u03b1<jats:sub>1<\/jats:sub> receptors with (<jats:italic>R<\/jats:italic>)\u2010isolaureline showing the greatest potency (p<jats:italic>K<\/jats:italic><jats:sub>b<\/jats:sub>\u00a0=\u00a08.14 at the 5\u2010HT<jats:sub>2C<\/jats:sub> receptor). Both (<jats:italic>R<\/jats:italic>)\u2010 and (<jats:italic>S<\/jats:italic>)\u2010glaucine also antagonized \u03b1<jats:sub>1<\/jats:sub> receptors, but they behaved very differently to the other compounds at 5\u2010HT<jats:sub>2<\/jats:sub> receptors: (<jats:italic>S<\/jats:italic>)\u2010glaucine acted as a partial agonist at all three 5\u2010HT<jats:sub>2<\/jats:sub> receptor subtypes, whereas (<jats:italic>R<\/jats:italic>)\u2010glaucine appeared to act as a positive allosteric modulator at the 5\u2010HT<jats:sub>2A<\/jats:sub> receptor.<\/jats:p>","DOI":"10.1111\/cbdd.13390","type":"journal-article","created":{"date-parts":[[2018,9,16]],"date-time":"2018-09-16T10:36:26Z","timestamp":1537094186000},"page":"132-138","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["In vitro functional evaluation of isolaureline, dicentrine and glaucine enantiomers at 5\u2010HT<sub>2<\/sub> and \u03b1<sub>1<\/sub> receptors"],"prefix":"10.1111","volume":"93","author":[{"given":"Hui Li","family":"Heng","sequence":"first","affiliation":[{"name":"Department of Pharmacy Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chin Fei","family":"Chee","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"},{"name":"Department of Chemistry Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Keng","family":"Thy","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia Ti","family":"Tee","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Malaya  Kuala Lumpur Malaysia"},{"name":"Department of Oral Biology and Craniofacial Sciences and Oral Cancer Research and Coordinating Centre Faculty of Dentistry University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sek Peng","family":"Chin","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"},{"name":"Department of Chemistry Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deron R.","family":"Herr","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Yong Loo Lin School of Medicine National University of Singapore  Singapore Singapore"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2438-2376","authenticated-orcid":false,"given":"Michael J. 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Rahman","sequence":"additional","affiliation":[{"name":"Department of Chemistry Faculty of Science University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lip Yong","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Faculty of Medicine University of Malaya  Kuala Lumpur Malaysia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2018,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2003.09.010"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2003.09.009"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0079-6123(08)00916-3"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1301263"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1741-2"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2030-4"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0707590"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm060959i"},{"key":"e_1_2_7_10_1","first-page":"643","volume":"3","author":"Cassels B. 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