{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T12:55:18Z","timestamp":1792500918607,"version":"4.5.0"},"reference-count":33,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2018,11,28]],"date-time":"2018-11-28T00:00:00Z","timestamp":1543363200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2019,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A new series of functionalized fused pyridines <jats:bold>4(a\u2013i)<\/jats:bold> and fused pyrido[2,3\u2010d]pyrimidines <jats:bold>8(a\u2013c)<\/jats:bold> were designed and synthesized through a multi\u2010component reaction where in pyridine ring formation step plays a key role. All the newly formed compounds were well characterized by spectral techniques such as <jats:styled-content style=\"fixed-case\">FTIR<\/jats:styled-content>, <jats:sup>1<\/jats:sup><jats:styled-content style=\"fixed-case\">HNMR<\/jats:styled-content>, <jats:sup>13<\/jats:sup><jats:styled-content style=\"fixed-case\">CNMR<\/jats:styled-content>,<jats:styled-content style=\"fixed-case\"> HRMS<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">XRD<\/jats:styled-content>. The potential therapeutic activities such as anti\u2010inflammatory activity by protein denaturation and <jats:styled-content style=\"fixed-case\">RBC<\/jats:styled-content> membrane stabilization methods, and anti\u2010oxidant activity by <jats:styled-content style=\"fixed-case\">DPPH<\/jats:styled-content> scavenging method of the newly synthesized compounds were studied. Interestingly, in\u2010vitro testing of these compounds reveals that the compounds <jats:bold>4d<\/jats:bold>,<jats:bold> 4g<\/jats:bold>,<jats:bold> 4i<\/jats:bold>,<jats:bold> 8a<\/jats:bold> and <jats:bold>8b<\/jats:bold> showed comparable anti\u2010inflammatory activity with respect to the standard drug, diclofenac. Similarly, fused pyridine <jats:bold>4f<\/jats:bold> showed excellent anti\u2010oxidant activity when compared with the standard, ascorbic acid.<\/jats:p>","DOI":"10.1111\/cbdd.13434","type":"journal-article","created":{"date-parts":[[2018,11,5]],"date-time":"2018-11-05T05:13:57Z","timestamp":1541394837000},"page":"464-472","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["One pot multi\u2010component synthesis of functionalized spiropyridine and pyrido[2,3\u2010<i>d<\/i>]pyrimidine scaffolds and their potent in\u2010vitro anti\u2010inflammatory and anti\u2010oxidant investigations"],"prefix":"10.1111","volume":"93","author":[{"given":"Mallu","family":"Lavanya","sequence":"first","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences VIT  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Indira Viswambaran","family":"Asharani","sequence":"additional","affiliation":[{"name":"Department of Chemistry School of Advanced Sciences VIT  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7591-4841","authenticated-orcid":false,"given":"Dhakshanamurthy","family":"Thirumalai","sequence":"additional","affiliation":[{"name":"Department of Chemistry Thiruvalluvar University  Vellore Tamil Nadu India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2018,11,28]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3762\/bjoc.9.265"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules180911338"},{"key":"e_1_2_8_4_1","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3998\/ark.5550190.p009.603","article-title":"Molecular diversity of four\u2010component synthesis of pyrazole\u2010based pyrido[2, 3\u2010d]pyrimidine\u2010diones in water: A green synthesis","volume":"4","author":"Daraie M.","year":"2016","journal-title":"Arkivoc"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00278a009"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr020004h"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr0505728"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/jhet.2487"},{"key":"e_1_2_8_9_1","first-page":"608","article-title":"Synthesis and pharmacological activities of fused pyrimidinones","volume":"2","author":"Farghaly T. 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