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Recently, our group has reported that the 8\u2010hydroxy\u20105\u2010quinolinesulfonic acid presents relevant antifungal activity. However, its intrinsic acidity could lead to an ionization process, decreasing fungal cell permeability. To overcome this potential problem and enhance activity, the purpose of this study was to synthesize and evaluate a novel series of hybrids between the 8\u2010hydroxyquinoline core and sulfonamide and to prove their potential using broth microdilution method, obtaining the pharmacodynamic parameters of the most active derivatives combining time\u2010kill studies and mathematical modeling and evaluating their toxicity. Compound <jats:bold>5a<\/jats:bold> was the most potent, being active against all the fungal species tested, with low toxicity in normal cells. <jats:bold>5a<\/jats:bold> and <jats:bold>5b<\/jats:bold> have presented important antibacterial activity against <jats:italic>Staphylococcus aureus<\/jats:italic> strain. The <jats:styled-content style=\"fixed-case\">EC<\/jats:styled-content><jats:sub>50<\/jats:sub> values obtained by combination of time\u2010kill studies with mathematical model were similar to those of <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content>, which confirms the potential of compounds. In addition, these derivatives are non\u2010irritant molecules with the absence of topical toxicity. Finally, <jats:bold>5a<\/jats:bold> and <jats:bold>5b<\/jats:bold> are promising candidates for treatment of dermatomycosis and candidiasis.<\/jats:p>","DOI":"10.1111\/cbdd.13435","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T11:50:27Z","timestamp":1542628227000},"page":"1186-1196","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Rapid tools to gain insights into the interaction dynamics of new 8\u2010hydroxyquinolines with few fungal lines"],"prefix":"10.1111","volume":"93","author":[{"given":"Ang\u00e9lica Rocha","family":"Joaquim","sequence":"first","affiliation":[{"name":"Pharmaceutical Synthesis Group (PHARSG) Universidade Federal do Rio Grande do Sul  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010gradua\u00e7\u00e3o em Ci\u00eancias Farmac\u00eauticas Universidade Federal do Rio Grande do Sul  Porto Alegre 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