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Nucleosides <jats:bold>3<\/jats:bold>\u2010<jats:bold>6<\/jats:bold> were resistant to deamination under action of adenosine deaminase (ADA) <jats:italic>Escherichia coli<\/jats:italic> and ADA from calf intestine. The antiviral activity of the modified nucleosides was evaluated against herpes simplex virus type 1 (HSV\u20101, strain L2). It has been shown that at sub\u2010toxic concentrations, nucleoside (<jats:italic>S<\/jats:italic>)\u20104\u2010[2\u2010amino\u20109\u2010(\u03b2\u2010<jats:italic>D<\/jats:italic>\u2010ribofuranosyl)\u2010purin\u20106\u2010yl]\u20107,8\u2010difluoro\u20103,4\u2010dihydro\u20103\u2010methyl\u20102<jats:italic>H<\/jats:italic>\u2010[1,4]benzoxazine exhibit significant antiviral activity (SI\u00a0&gt;\u00a032) on the model of HSV\u20101 in vitro, including an acyclovir\u2010resistant virus strain (HSV\u20101, strain L2\/R).<\/jats:p>","DOI":"10.1111\/cbdd.13458","type":"journal-article","created":{"date-parts":[[2018,12,18]],"date-time":"2018-12-18T16:00:38Z","timestamp":1545148838000},"page":"605-616","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Enzymatic synthesis of novel purine nucleosides bearing a chiral benzoxazine fragment"],"prefix":"10.1111","volume":"93","author":[{"given":"Barbara Z.","family":"Eletskaya","sequence":"first","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dmitry A.","family":"Gruzdev","sequence":"additional","affiliation":[{"name":"Postovsky Institute of Organic Synthesis Russian Academy of Sciences (Ural Branch)  Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victor P.","family":"Krasnov","sequence":"additional","affiliation":[{"name":"Postovsky Institute of Organic Synthesis Russian Academy of Sciences (Ural Branch)  Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Galina L.","family":"Levit","sequence":"additional","affiliation":[{"name":"Postovsky Institute of Organic Synthesis Russian Academy of Sciences (Ural Branch)  Ekaterinburg Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria A.","family":"Kostromina","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexander S.","family":"Paramonov","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexei L.","family":"Kayushin","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inessa S.","family":"Muzyka","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatyana I.","family":"Muravyova","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roman S.","family":"Esipov","sequence":"additional","affiliation":[{"name":"Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry Russian Academy of Sciences  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria L.","family":"Andronova","sequence":"additional","affiliation":[{"name":"Ivanovsky Institute of Virology (Gamaleya Research Center of Epidemiology and Microbiology Ministry of Healthcare of the Russian Federation)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgiy A.","family":"Galegov","sequence":"additional","affiliation":[{"name":"Ivanovsky Institute of Virology (Gamaleya Research Center of Epidemiology and Microbiology Ministry of Healthcare of the Russian Federation)  Moscow Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery N.","family":"Charushin","sequence":"additional","affiliation":[{"name":"Postovsky Institute of Organic Synthesis Russian Academy of Sciences (Ural Branch)  Ekaterinburg Russia"},{"name":"Ural Federal University named after the first President of Russia B.N. 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