{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T20:01:30Z","timestamp":1775678490465,"version":"3.50.1"},"reference-count":22,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2019,7,10]],"date-time":"2019-07-10T00:00:00Z","timestamp":1562716800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2019,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of new fluoroquinolone analogs (<jats:bold>3<\/jats:bold>\u2013<jats:bold>18)<\/jats:bold> were prepared, in three steps, by substituting chloro esters and esters with cyclic amines on the C\u20107 <jats:italic>endo<\/jats:italic>\u2010nortropine derivatives of difluoroquinolone acid. All the synthesized compounds displayed good <jats:styled-content style=\"fixed-case\">MIC<\/jats:styled-content> against the <jats:italic>Staphylococcus aureus<\/jats:italic> when initially screened for <jats:italic>Escherichia coli<\/jats:italic>,<jats:italic> S.\u00a0aureus, Klebsiella pneumoniae<\/jats:italic>,<jats:italic> Acinetobacter baumannii,<\/jats:italic> and <jats:italic>Pseudomonas aeruginosa<\/jats:italic>. The molecules were further evaluated for their antibacterial activity against fluoroquinolone\u2010resistant strains of <jats:italic>S.\u00a0aureus<\/jats:italic> and for cytotoxic assay. Based on the results, five of the sixteen compounds displayed the potential to be developed further for treatment against fluoroquinolone\u2010resistant strains of <jats:italic>S.\u00a0aureus<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/cbdd.13513","type":"journal-article","created":{"date-parts":[[2019,3,12]],"date-time":"2019-03-12T10:34:20Z","timestamp":1552386860000},"page":"1626-1633","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["New fluoroquinolone compounds with <i>endo<\/i>\u2010nortropine derivatives at C\u20107 position show antibacterial activity against fluoroquinolone\u2010resistant strains of <i>Staphylococcus aureus<\/i>"],"prefix":"10.1111","volume":"94","author":[{"given":"Ramkrushna Ashok","family":"Salunke","sequence":"first","affiliation":[{"name":"School of Chemistry and Biochemistry Thapar Institute of Engineering and Technology Patiala India"},{"name":"Saurav Chemicals Limited Derabassi\u2010 Mohali India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manjulika","family":"Shukla","sequence":"additional","affiliation":[{"name":"CDRI - Division of Microbiology CSIR\u2010Central Drug Research Institute Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grace","family":"Kaul","sequence":"additional","affiliation":[{"name":"CDRI - Division of Microbiology CSIR\u2010Central Drug Research Institute Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Baldev Raj","family":"Bansal","sequence":"additional","affiliation":[{"name":"Saurav Chemicals Limited Derabassi\u2010 Mohali India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sidharth","family":"Chopra","sequence":"additional","affiliation":[{"name":"CDRI - Division of Microbiology CSIR\u2010Central Drug Research Institute Lucknow India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8468-1111","authenticated-orcid":false,"given":"Manmohan","family":"Chhibber","sequence":"additional","affiliation":[{"name":"School of Chemistry and Biochemistry Thapar Institute of Engineering and Technology Patiala India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,7,10]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1517\/14656566.7.14.1957"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2017.1386654"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0b013e32834a88af"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9343(87)90622-X"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/383219a0"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/33.4.685"},{"key":"e_1_2_7_8_1","first-page":"351","article-title":"Resent updates of fluoroquinolones as antibacterial agent","author":"Ezelarab H. 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