{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:22Z","timestamp":1787013982947,"version":"build-2736575974"},"reference-count":71,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,16]],"date-time":"2020-02-16T00:00:00Z","timestamp":1581811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20160520153JH"],"award-info":[{"award-number":["20160520153JH"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011789","name":"Department of Science and Technology of Jilin Province","doi-asserted-by":"publisher","award":["20180101146JC & 20180414063GH"],"award-info":[{"award-number":["20180101146JC & 20180414063GH"]}],"id":[{"id":"10.13039\/501100011789","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Corneal neovascularization (\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    ), a pathological process of angiogenesis, can lead to serious consequences in the cornea.\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    is generally proved to associate with inflammation in the cornea closely, which is mainly elicited by the disruption of equilibrium between angiogenic and antiangiogenic factors. Angiogenic factors including vascular endothelial growth factors (\n                    <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                    s), basic fibroblast growth factors (\n                    <jats:styled-content style=\"fixed-case\">bFGF<\/jats:styled-content>\n                    s), and matrix metalloproteinases (\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    s) are vital factors in the formation of\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    . Especially\n                    <jats:styled-content style=\"fixed-case\">VEGF<\/jats:styled-content>\n                    s are convinced to be the core angiogenic factors in\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    , and\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    s are proved to exert dual effects on the process. Strikingly, matrix metalloproteinase 2 (\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    \u20102) and matrix metalloproteinase 9 (\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    \u20109) are determined to play key roles in the formation of\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    , while the mechanism is still vague. In this review, the latest researches are reviewed to discuss the role of\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    \u20102 and\n                    <jats:styled-content style=\"fixed-case\">MMP<\/jats:styled-content>\n                    \u20109 in\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    , respectively, and some inhibitors of them are presented. We hope to provide a new direction of drug research for\n                    <jats:styled-content style=\"fixed-case\">CNV<\/jats:styled-content>\n                    .\n                  <\/jats:p>","DOI":"10.1111\/cbdd.13529","type":"journal-article","created":{"date-parts":[[2019,4,19]],"date-time":"2019-04-19T09:43:37Z","timestamp":1555667017000},"page":"485-492","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Regulation of matrix metalloproteinases 2 and 9 in corneal neovascularization"],"prefix":"10.1111","volume":"95","author":[{"given":"Jiahao","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology 2nd Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shurong","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 2nd Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxi","family":"He","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 2nd Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boyuan","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 2nd Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6149-4054","authenticated-orcid":false,"given":"Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology 2nd Hospital of Jilin University Changchun China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,16]]},"reference":[{"issue":"4","key":"e_1_2_8_2_1","first-page":"265","article-title":"Membrane type\u20101 matrix metalloproteinase (MT1\u2010MMP) correlates with the expression and activation of matrix metalloproteinase\u20102 (MMP\u20102) in inflammatory breast cancer","volume":"4","author":"Al\u2010Raawi D.","year":"2011","journal-title":"International Journal of Clinical and Experimental Medicine"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.00063"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/35036374"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1999.tb07675.x"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2010.01.003"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/00055735-200108000-00002"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2015.11.006"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0094205"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.12-10891"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.03.056"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.pmbts.2017.02.005"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2011.204701"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.00821-07"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2016.12.010"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-017-3651-8"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.2353\/ajpath.2010.080642"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/2045-824X-3-2"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1535-6108(03)00133-8"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.16-19420"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.20945"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10384-007-0487-5"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI10403"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2013.874443"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000001127"},{"issue":"5","key":"e_1_2_8_26_1","first-page":"1048","article-title":"Reduced angiogenesis and tumor progression in gelatinase A\u2010deficient mice","volume":"58","author":"Itoh T.","year":"1998","journal-title":"Cancer Research"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-5793(01)02897-6"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-18701"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e318241433b"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep19408"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.10.006"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13018"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1159\/000055693"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2011.01.041"},{"issue":"2","key":"e_1_2_8_35_1","first-page":"162","article-title":"Triamcinolone acetonide as an adjunct to bevacizumab for prevention of corneal neovascularization in a rat model","volume":"9","author":"Mehrjardi H. Z.","year":"2014","journal-title":"Journal of Ophthalmic & Vision Research"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/eye.2011.246"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.275.14.10405"},{"issue":"9","key":"e_1_2_8_38_1","doi-asserted-by":"crossref","first-page":"6632","DOI":"10.1016\/S0021-9258(17)37419-7","article-title":"Assessment of the role of the fibronectin\u2010like domain of gelatinase A by analysis of a deletion mutant","volume":"269","author":"Murphy G.","year":"1994","journal-title":"Journal of Biological Chemistry"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cardiores.2005.12.002"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1357-2725(00)00013-3"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/8620172"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207688"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2007.06.004"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3182542613"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2008.05.001"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/vop.12032"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm846"},{"issue":"5","key":"e_1_2_8_48_1","first-page":"5831","article-title":"Ginkgolic acid inhibits the invasiveness of colon cancer cells through AMPK activation","volume":"14","author":"Qiao L.","year":"2017","journal-title":"Oncology Letters"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3HI1216-511RR"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12152"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2014.03.004"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1087-0024.2000.00004.x"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2010.05.003"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2018.06.004"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.3109\/02713683.2010.502294"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.4335"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1350-9462(01)00015-5"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvm102"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2013.11.002"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2005.07.047"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.0000070112.80711.3D"},{"issue":"4","key":"e_1_2_8_62_1","first-page":"444","article-title":"Corneal neovascularization and biological therapy","volume":"8","author":"Voiculescu O. B.","year":"2015","journal-title":"Journal of Medicine and Life"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81169-1"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2015.01.016"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0041858"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.1089\/jmf.2014.3404"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12013-017-0790-9"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.gt.3302442"},{"key":"e_1_2_8_69_1","first-page":"688","article-title":"Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice","volume":"21","author":"Zeng P.","year":"2015","journal-title":"Molecular Vision"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2017.12.008"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.060037197"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.22835"}],"container-title":["Chemical Biology &amp; Drug Design"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcbdd.13529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.13529","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cbdd.13529","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cbdd.13529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,7]],"date-time":"2023-09-07T00:42:05Z","timestamp":1694047325000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cbdd.13529"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,16]]},"references-count":71,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5]]}},"alternative-id":["10.1111\/cbdd.13529"],"URL":"https:\/\/doi.org\/10.1111\/cbdd.13529","archive":["Portico"],"relation":{},"ISSN":["1747-0277","1747-0285"],"issn-type":[{"value":"1747-0277","type":"print"},{"value":"1747-0285","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,16]]},"assertion":[{"value":"2019-01-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-03-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}