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Subsequent tests revealed the compounds act by inhibiting lipid peroxidation, a trigger for a form of regulated cell death known as ferroptosis. A quantitative structure\u2013activity study together with XED (eXtended Electron Distributions) field analysis allowed a qualitative understanding of the structure\u2013activity relationships. A representative compound N\u2010(3,5\u2010dimethyl\u20104H\u20101,2,4\u2010triazol\u20104\u2010yl)\u201010H\u2010phenothiazine\u201010\u2010carboxamide (DT\u2010PTZ\u2010C) was able to inhibit completely oxidative damage brought about by two different procedures in organotypic hippocampal slice cultures, displaying a 30\u2010 to 100\u2010fold higher potency than the standard vitamin E analogue, Trolox or edaravone. 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