{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T03:48:24Z","timestamp":1783223304002,"version":"3.54.6"},"reference-count":31,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,7,21]],"date-time":"2019-07-21T00:00:00Z","timestamp":1563667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2018\/28\/T\/ST5\/00041"],"award-info":[{"award-number":["2018\/28\/T\/ST5\/00041"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Monensin A (<jats:bold>MON<\/jats:bold>) is a polyether ionophore antibiotic, which shows a wide spectrum of biological activity, including anticancer activity. A series of structurally diverse monensin esters including its C\u20101 esters (<jats:bold>1<\/jats:bold>\u2013<jats:bold>9<\/jats:bold>), C\u201026\u2010<jats:italic>O<\/jats:italic>\u2010acetylated derivatives (<jats:bold>10<\/jats:bold>\u2013<jats:bold>15<\/jats:bold>), and lactone (<jats:bold>16<\/jats:bold>) was synthesized and for the first time evaluated for their antiproliferative activity against four human cancer cell lines with different drug\u2010sensitivity level. All of the <jats:bold>MON<\/jats:bold> derivatives exhibited in vitro antiproliferative activity against cancer cells at micromolar concentrations. The majority of the compounds was able to overcome the drug resistance of LoVo\/DX and MES\u2010SA\/DX5 cell lines. The most active compounds proved to be <jats:bold>MON<\/jats:bold> C\u201026\u2010<jats:italic>O<\/jats:italic>\u2010acetylated derivatives (<jats:bold>10<\/jats:bold>\u2013<jats:bold>15<\/jats:bold>) which exhibited very good resistance index and high selectivity index.<\/jats:p>","DOI":"10.1111\/cbdd.13581","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T15:45:03Z","timestamp":1561995903000},"page":"1859-1864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antiproliferative activity of ester derivatives of monensin A at the C\u20101 and C\u201026 positions"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9365-4238","authenticated-orcid":false,"given":"Greta","family":"Klejborowska","sequence":"first","affiliation":[{"name":"Department of Bioorganic Chemistry Faculty of Chemistry Adam Mickiewicz University Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"J\u0119drzejczyk","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry Faculty of Chemistry Adam Mickiewicz University Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"St\u0119pczy\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry Faculty of Chemistry Adam Mickiewicz University Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5205-8712","authenticated-orcid":false,"given":"Ewa","family":"Maj","sequence":"additional","affiliation":[{"name":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4980-6606","authenticated-orcid":false,"given":"Joanna","family":"Wietrzyk","sequence":"additional","affiliation":[{"name":"Hirszfeld Institute of Immunology and Experimental Therapy Polish Academy of Sciences Wroc\u0142aw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4770-215X","authenticated-orcid":false,"given":"Adam","family":"Huczy\u0144ski","sequence":"additional","affiliation":[{"name":"Department of Bioorganic Chemistry Faculty of Chemistry Adam Mickiewicz University Pozna\u0144 Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,7,21]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00998a062"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2015.01.005"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12602"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.02.031"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/9783527684403.ch6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01155a084"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.3382\/ps.2010-00931"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja00836a036"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(96)00176-1"},{"issue":"5","key":"e_1_2_7_11_1","first-page":"1149","article-title":"Analogs of monensin with a modified c25\u2013c26 moiety: Na+\/k+ selectivity and biological activity","volume":"54","author":"Gaboyard C.","year":"1990","journal-title":"Agricultural and Biological Chemistry"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tetlet.2008.06.116"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2015.08.067"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2006.03.014"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molstruc.2005.11.032"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tet.2007.06.022"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp062160o"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2008.03.038"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-09-1035"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-10-0368"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.13320"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040-4020(01)88185-0"},{"issue":"2","key":"e_1_2_7_23_1","first-page":"377","article-title":"Monensin\u2010mediated growth inhibition of SNU\u2010C1 colon cancer cells via cell cycle arrest and apoptosis","volume":"22","author":"Park W. 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