{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T12:36:55Z","timestamp":1791549415185,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,8,27]],"date-time":"2019-08-27T00:00:00Z","timestamp":1566864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100000265","name":"Medical Research Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000265","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011512","name":"National Research Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011512","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of 3',4'\u2010dihydro\u20101'<jats:italic>H<\/jats:italic>\u2010spiro(indoline\u20103,2'\u2010quinolin)\u20102\u2010ones were prepared by the inverse\u2010electron\u2010demand aza\u2010Diels\u2013Alder reaction (Povarov reaction) of imines derived from isatin and substituted anilines, and the electron\u2010rich alkenes <jats:italic>trans\u2010<\/jats:italic>isoeugenol and 3,4\u2010dihydro\u20102<jats:italic>H<\/jats:italic>\u2010pyran. These compounds were assessed for in vitro antiplasmodial activity against drug\u2010sensitive and drug\u2010resistant forms of the <jats:italic>P.\u00a0falciparum<\/jats:italic> parasite. Three compounds derived from 3,4\u2010dihydro\u20102<jats:italic>H<\/jats:italic>\u2010pyran and four compounds derived from <jats:italic>trans\u2010<\/jats:italic>isoeugenol showed antiplasmodial activity in the low micromolar range against the drug\u2010resistant FCR\u20103 strain (1.52\u20134.20\u00a0\u00b5M). Only compounds derived from <jats:italic>trans\u2010<\/jats:italic>isoeugenol showed antiplasmodial activity against the drug\u2010sensitive 3D7 strain (1.31\u20131.80\u00a0\u00b5M).<\/jats:p>","DOI":"10.1111\/cbdd.13598","type":"journal-article","created":{"date-parts":[[2019,7,30]],"date-time":"2019-07-30T14:07:21Z","timestamp":1564495641000},"page":"1849-1858","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Preparation and antiplasmodial activity of 3',4'\u2010dihydro\u20101'<i>H<\/i>\u2010spiro(indoline\u20103,2'\u2010quinolin)\u20102\u2010ones"],"prefix":"10.1111","volume":"94","author":[{"given":"Bakolise","family":"Mathebula","sequence":"first","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamogelo Rosinah","family":"Butsi","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry University of the Witwatersrand Johannesburg South Africa"},{"name":"Faculty of Health Sciences WITS Research Institute for Malaria (WRIM), University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn Lynne","family":"van Zyl","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences WITS Research Institute for Malaria (WRIM), University of the Witwatersrand Johannesburg South Africa"},{"name":"Pharmacology Division, Department of Pharmacy and Pharmacology, Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha Colleen","family":"Jansen van Vuuren","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences WITS Research Institute for Malaria (WRIM), University of the Witwatersrand Johannesburg South Africa"},{"name":"Pharmacology Division, Department of Pharmacy and Pharmacology, Faculty of Health Sciences University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heinrich Carl","family":"Hoppe","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Microbiology Rhodes University Grahamstown South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph Philip","family":"Michael","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles Bernard","family":"de Koning","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-1797","authenticated-orcid":false,"given":"Amanda Louise","family":"Rousseau","sequence":"additional","affiliation":[{"name":"Molecular Sciences Institute, School of Chemistry University of the Witwatersrand Johannesburg South Africa"},{"name":"Faculty of Health Sciences WITS Research Institute for Malaria (WRIM), University of the Witwatersrand Johannesburg South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6QO00037A"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.16.6.710"},{"issue":"04","key":"e_1_2_8_4_1","first-page":"489","article-title":"Povarov reaction of B\u2010enamino esters and isatin\u20103\u2010imines for diastereoselective synthesis of 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