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The glycoproteins of HSV\u20101 such as glycoprotein B, glycoprotein C, glycoprotein D, glycoprotein H, and glycoprotein L are highly involved in mediating the viral attachment and infection of the host cell. Therefore, immunoinformatic approaches followed by molecular dynamics simulation and systems biology has been used to analyze these glycoproteins in order to propose effective peptide\u2010based vaccine candidates against the HSV\u20101 infection. The ElliPro and NetCTL.1.2 online tools were employed to forecast the B\u2010 and T\u2010lymphocyte (CTL) epitopes for gB, gC, gD, gH, and gL. The 3D coordinates of these epitopes were modeled and docked against the human major histocompatibility complex molecule\u20101. The outcomes obtained from postdocking analysis along with TAP (Transporter associated with antigen processing), MHC binding, and C\u2010terminal cleavage score assisted in the selection of potential epitopes. These epitopes were further subjected to molecular dynamics simulation and systems biology approach which showed significant results. On the basis of these substantial outcomes, peptides are proposed that could be used to provoke immunity against the HSV\u20101 infection.<\/jats:p>","DOI":"10.1111\/cbdd.13602","type":"journal-article","created":{"date-parts":[[2019,8,22]],"date-time":"2019-08-22T21:40:27Z","timestamp":1566510027000},"page":"1868-1883","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Prediction and validation of potent peptides against herpes simplex virus type 1 via immunoinformatic and systems biology approach"],"prefix":"10.1111","volume":"94","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8713-966X","authenticated-orcid":false,"given":"Aamir","family":"Mehmood","sequence":"first","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism College of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aman Chandra","family":"Kaushik","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism College of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4200-7502","authenticated-orcid":false,"given":"Dong\u2010Qing","family":"Wei","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Microbial Metabolism College of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,9,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btv639"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/prot.21495"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10090473"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13073-015-0245-0"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10070360"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm400771k"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gki396"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.040238-0"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2007.03.010"},{"key":"e_1_2_10_11_1","volume-title":"The PyMOL molecular graphics system","author":"DeLano W. 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