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These are the important category of heterocycles, which may be formally derived from benzene and its reduction products by convenient substitution of carbon (and hydrogen) atoms by nitrogen and oxygen. In the last few decades, oxazine derivatives have documented as worthy synthetic intermediates and also blessed with notable sedative, analgesic, anticonvulsant, antipyretic, antimicrobial, antitubercular, antimalarial, antioxidant, and anticancer activities. Nowadays, it is important to develop new classes of compounds with more effective mechanisms due to drug resistance activity in which the ability of drug to effectively treat disease can be reduced. The aim of the article is to collect and make a more generalized review on the synthesis of oxazine derivatives and their pharmaceutical and biological activities. We hope this review will provide ample references for the researchers concerned with azines in generally and oxazines in particular.<\/jats:p>","DOI":"10.1111\/cbdd.13633","type":"journal-article","created":{"date-parts":[[2019,10,4]],"date-time":"2019-10-04T04:35:26Z","timestamp":1570163726000},"page":"16-47","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":94,"title":["Medicinal chemistry of oxazines as promising agents in drug discovery"],"prefix":"10.1111","volume":"95","author":[{"given":"Dhafer S.","family":"Zinad","sequence":"first","affiliation":[{"name":"Applied Science Department University of Technology Baghdad Iraq"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6977-3752","authenticated-orcid":false,"given":"Ahmed","family":"Mahal","sequence":"additional","affiliation":[{"name":"Key Laboratory of Plant Resources Conservation and Sustainable Utilization and Guangdong Provincial Key Laboratory of Applied Botany South China Botanical Garden Chinese Academy of Sciences Guangzhou China"},{"name":"Guangzhou HC Pharmaceutical Co., Ltd. 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