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As a new drug delivery pathway, nanoliposomes have the advantages of simplifying metabolism, reducing drug side\u2010effects, and providing specific targeting, which can potentially improve the therapeutic effect toward tumor therapy. In this study, a clinically integrated nanoliposome containing Sertraline Hydrochloride and indocyanine green (ICG), here named as Ser\/ICG@Lip, was successfully synthesized by film\u2010dispersion and hydration\u2013sonication methods. The photoacoustic imaging and near\u2010infrared fluorescence imaging capabilities of this novel nanoliposome were validated in vitro. The high encapsulation rate of Sertraline Hydrochloride and ICG ensured the safety and therapeutic efficacy of the particle. Moreover, our results suggest that chemo\u2010photothermal combination therapy can be more effective than single photothermal or chemotherapy treatments against malignant tumor cells. This is the first study introducing Sertraline Hydrochloride as a liposome\u2010encapsulated chemotherapeutic agent, containing photothermal capabilities, for the treatment of metastatic renal clear cell cancer cells. This novel drug system has potential to evolve into an alternate treatment method for metastatic clear cell renal cell carcinoma.<\/jats:p>","DOI":"10.1111\/cbdd.13652","type":"journal-article","created":{"date-parts":[[2019,12,10]],"date-time":"2019-12-10T03:54:52Z","timestamp":1575950092000},"page":"320-331","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Sertraline\/ICG\u2010loaded liposome for dual\u2010modality imaging and effective chemo\u2010photothermal combination therapy against metastatic clear cell renal cell carcinoma"],"prefix":"10.1111","volume":"95","author":[{"given":"Yuting","family":"Lei","sequence":"first","affiliation":[{"name":"Department of Nephrology the Second Affiliated Hospital of Chongqing Medical University Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Nephrology the 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