{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T13:09:53Z","timestamp":1770815393685,"version":"3.50.1"},"reference-count":45,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":20,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Irbesartan (IRB) exerts beneficial effects either alone or in combination with other drugs on numerous diseases, such as cancer, diabetes, and hypertension. However, due to its high lipophilicity, IRB does not possess the optimum pharmacological efficiency. To circumvent this problem, a drug delivery system with 2\u2010hydroxypropyl\u2010\u03b2\u2010cyclodextrin (2\u2010HP\u2010\u03b2\u2010CD) was explored. The 1:1 complex between IRB and 2\u2010HP\u2010\u03b2\u2010CD was identified through ESI QTF HRMS. Dissolution studies showed a higher dissolution rate of the lyophilized IRB\u20132\u2010HP\u2010\u03b2\u2010CD complex than the tablet containing IRB at pH\u00a0=\u00a01.2. DSC results revealed the differences of the thermal properties between the complex and various mixtures consisting of the two components, namely IRB and 2\u2010HP\u2010\u03b2\u2010CD. Interestingly, depending on the way the mixture preparation was conducted, different association between the two components was observed. Molecular dynamics (MD) simulations predicted the favorable formation of the above complex and identified the dominant interactions between IRB and 2\u2010HP\u2010\u03b2\u2010CD.<jats:italic>In vitro<\/jats:italic>pharmacological results verified that the inclusion complex not only preserves the binding affinity of IRB for AT1R receptor, but also it slightly increases it. As the complex formulation lacks the problems of the tablet, our approach is a promising new way to improve the efficiency of IRB.<\/jats:p>","DOI":"10.1111\/cbdd.13664","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T11:23:19Z","timestamp":1595330599000},"page":"668-683","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Antihypertensive activity and molecular interactions of irbesartan in complex with 2\u2010hydroxypropyl\u2010\u03b2\u2010cyclodextrin"],"prefix":"10.1111","volume":"96","author":[{"given":"Georgios","family":"Leonis","sequence":"first","affiliation":[{"name":"Laboratory of Organic Chemistry Department of Chemistry National and Kapodistrian University of Athens Zografou Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1902-9666","authenticated-orcid":false,"given":"Eirini","family":"Christodoulou","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry Department of Chemistry National and Kapodistrian University of Athens Zografou Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Ntountaniotis","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry Department of Chemistry National and Kapodistrian University of Athens Zografou Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria V.","family":"Chatziathanasiadou","sequence":"additional","affiliation":[{"name":"Department of Chemistry Section of Organic Chemistry and Biochemistry University of Ioannina Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5309-992X","authenticated-orcid":false,"given":"Thomas","family":"Mavromoustakos","sequence":"additional","affiliation":[{"name":"Laboratory of Organic Chemistry Department of Chemistry National and Kapodistrian University of Athens Zografou Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8155-3875","authenticated-orcid":false,"given":"Nikolaos","family":"Naziris","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical Technology Department of Pharmacy School of Health Sciences National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Chountoulesi","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical Technology Department of Pharmacy School of Health Sciences National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Costas","family":"Demetzos","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical Technology Department of Pharmacy School of Health Sciences National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgia","family":"Valsami","sequence":"additional","affiliation":[{"name":"Section of Pharmaceutical Technology Department of Pharmacy School of Health Sciences National and Kapodistrian University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2997-7566","authenticated-orcid":false,"given":"Dimitrios E.","family":"Damalas","sequence":"additional","affiliation":[{"name":"Department of Chemistry Laboratory of Analytical Chemistry National and Kapodistrian University of Athens Zografou Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas G.","family":"Tzakos","sequence":"additional","affiliation":[{"name":"Department of Chemistry Section of Organic Chemistry and Biochemistry University of Ioannina Ioannina Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos S.","family":"Thomaidis","sequence":"additional","affiliation":[{"name":"Department of Chemistry Laboratory of Analytical Chemistry National and Kapodistrian University of Athens Zografou Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vlasios","family":"Karageorgos","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences School of Medicine University of Crete Heraklion Crete Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgios","family":"Liapakis","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences School of Medicine University of Crete Heraklion Crete Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,7,21]]},"reference":[{"issue":"1","key":"e_1_2_9_2_1","first-page":"22","article-title":"Irbesartan: review of pharmacology and comparative properties","volume":"7","author":"Adams M. 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