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Conventional treatment methodologies used to deal with amoebiasis mainly rely on the administration of anti\u2010amoebic compounds and vaccines but are often linked with substantial side\u2010effects on the patient. Besides, cases of development of drug resistance in protozoans have been recorded, contributing further to the reduction in the efficiency of the treatment. Loopholes in the efficacious management of the disease call for the development of novel methodologies to manage amoebiasis. A way to achieve this is by targeting the essential metabolic processes of \u2018encystation\u2019 and \u2018excystation\u2019, and the associated biomolecules, thus interrupting the biphasic life cycle of the parasite. Technologies like the CRISPR\u2010Cas9 system can efficiently be exploited to discover novel and essential molecules that regulate the protozoan's metabolism, while efficiently manipulating and managing the known drug targets, leading to an effective halt and forestall to the enteric infection. This review presents a perspective on these essential metabolic processes and the associated molecules that can be targeted efficaciously to prevent the transmission of amoebiasis, thus managing the disease and proving to be a fruitful endeavour.<\/jats:p>","DOI":"10.1111\/cbdd.13699","type":"journal-article","created":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T05:29:25Z","timestamp":1588310965000},"page":"731-744","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Averting transmission: A pivotal target to manage amoebiasis"],"prefix":"10.1111","volume":"96","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9136-6478","authenticated-orcid":false,"given":"Aadish","family":"Rawat","sequence":"first","affiliation":[{"name":"Amity Institute of Biotechnology Amity University Rajasthan Jaipur 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