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This new complex has a high capacity to inhibit the proliferation of prostate cancer cells (IC<jats:sub>50<\/jats:sub>\u00a0=\u00a01.92\u00a0\u03bcg\/ml). This activity could be attributed to its ability to induce mitochondrial fragmentation through increasing mitochondrial fission dynamin\u2010related protein 1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05) and down\u2010regulation of optic atrophy 1 proteins (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05). Moreover, this complex can effectively disrupt ATP synthase action leading to declined ATP production, along with downstream of ATPase inhibitor factor1 that hinder energy production in the cancer cells. Also, it has an anti\u2010inflammatory effect by triggering modulators for the release of inflammatory molecules such as TNF\u2010\u03b1 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), IL\u20106 (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.05), and mRNA transcripts of COX\u2010II (<jats:italic>p<\/jats:italic>\u00a0&lt;\u00a0.01). Therefore, Pd(II)COS@GbA exhibited significant anti\u2010prostate cancer activity through different mechanisms in inducing energy depletion and mitochondrial fragmentation leading to disrupted oxidative phosphorylation (OXPHOS). Complex Pd(II)COS@GbA is more cytotoxic for PC3 than RWPE\u20101 which in turn means it is may act as a selective cytotoxic agent for prostate cancer.<\/jats:p>","DOI":"10.1111\/cbdd.13703","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T08:45:15Z","timestamp":1589359515000},"page":"1148-1161","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Role of Pd(II)\u2013chitooligosaccharides\u2013Gboxin analog in oxidative phosphorylation inhibition and energy depletion: Targeting mitochondrial dynamics"],"prefix":"10.1111","volume":"96","author":[{"given":"Serag Eldin I.","family":"Elbehairi","sequence":"first","affiliation":[{"name":"Biology Department Faculty of Science King Khalid University Abha Saudi Arabia"},{"name":"Cell Culture Lab Egyptian Organization for Biological Products and Vaccines (VACSERA Holding Company) Giza Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammad Y.","family":"Alfaifi","sequence":"additional","affiliation":[{"name":"Biology Department Faculty of Science King Khalid University Abha Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A.","family":"Shati","sequence":"additional","affiliation":[{"name":"Biology Department Faculty of Science King Khalid University Abha Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mohammed A.","family":"Alshehri","sequence":"additional","affiliation":[{"name":"Biology Department Faculty of Science King Khalid University Abha Saudi Arabia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-8928","authenticated-orcid":false,"given":"Reda F.M.","family":"Elshaarawy","sequence":"additional","affiliation":[{"name":"Chemistry Department Faculty of Science Suez University Suez Egypt"},{"name":"Institut f\u00fcr Anorganische Chemie und Strukturchemie Heinriche\u2010Heine\u2010Universit\u00e4t D\u00fcsseldorf D\u00dcSSELDORF Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hani S.","family":"Hafez","sequence":"additional","affiliation":[{"name":"Zoology Department Faculty of Science Suez University Suez Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,8,19]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/2952085"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jphotochem.2019.112083"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1215233"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/md15040096"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28518"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00001.2015"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2009.07.019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.07.016"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2017.00081"},{"issue":"7","key":"e_1_2_8_11_1","first-page":"253","article-title":"Chitosan\u2010based drug delivery systems for optimization of photodynamic therapy: A Review","volume":"20","author":"Calixto G. 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