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Mice were randomized into three groups: AMI group, AMI with atorvastatin treatment (T\u2010AMI) group, and sham group. Three groups of model mice were randomly selected at day 1 (D1), day 3 (D3), and day 7 (D7) day after surgery with\n                    <jats:sup>99m<\/jats:sup>\n                    Tc\u2010Duramycin micro\u2010SPECT\/CT imaging. The lesion\u2010to\u2010normal myocardial tissue ratio (L\/N) average values were 2.62 on D1, 3.89 on D3, and 1.20 on D7 for the uptake of\n                    <jats:sup>99m<\/jats:sup>\n                    Tc\u2010duramycin in the infarcted region in the AMI group. The sham group presented no positive imaging in myocardium, and the L\/N average values were 1.09, 1.14, and 1.10 on D1, D3, and D7, respectively. Meanwhile,\n                    <jats:sup>99m<\/jats:sup>\n                    Tc\u2010linear\u2010duramycin imaging showed no radioactive uptake in the infarction region. The T\u2010AMI group imaging showed tracer uptake decreased obviously compared to the uptake in the infarcted region in AMI mice.\n                    <jats:sup>99m<\/jats:sup>\n                    Tc\u2010Duramycin SPECT\/CT imaging allowed non\u2010invasive monitoring of myocardial cell death in a mouse model of AMI and an assessment of atorvastatin anti\u2010apoptosis effect for cardioprotection by in vivo molecular imaging.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.13773","type":"journal-article","created":{"date-parts":[[2020,9,3]],"date-time":"2020-09-03T08:46:32Z","timestamp":1599122792000},"page":"210-220","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<sup>99m<\/sup>\n                    Tc\u2010labeled Duramycin for detecting and monitoring cardiomyocyte death and assessing atorvastatin cardioprotection in acute myocardial 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