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All compounds were synthesized according to a well\u2010known two\u2010step procedure involving alkylation of \u03b3\u2010picoline with appropriate alkyl bromide and further condensation with substituted benzaldehyde. Compounds with long <jats:italic>N<\/jats:italic>\u2010alkyl chains <jats:bold>(<\/jats:bold>C<jats:sub>18<\/jats:sub>H<jats:sub>37<\/jats:sub>\u2013C<jats:sub>20<\/jats:sub>H<jats:sub>41<\/jats:sub>) had no antifungal activity against the cells of all tested <jats:italic>C.\u00a0albicans<\/jats:italic> strains. Other styrylpyridinium compounds were able to inhibit yeast growth at the concentrations of 0.06\u201316\u00a0\u03bcg\/ml. At fungicidal concentrations, the compound with the CN\u2010 group was least toxic to mammalian cells, showed the most effective synergism with fluconazole, and only slightly inhibited the respiration of <jats:italic>C.\u00a0albicans<\/jats:italic>. The compound with the 4\u2032\u2010diethylamino group exhibited the strongest fungicidal properties and effectively blocked the respiration of <jats:italic>C.\u00a0albicans<\/jats:italic> cells. However, toxicity to mammalian cells was also high. Summarizing, the results of our study indicate that styrylpyridinium compounds are promising candidates in the development of new antifungal drugs.<\/jats:p>","DOI":"10.1111\/cbdd.13777","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T20:15:20Z","timestamp":1597004120000},"page":"253-265","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Antifungal activity of styrylpyridinium compounds against <i>Candida albicans<\/i>"],"prefix":"10.1111","volume":"97","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6550-1485","authenticated-orcid":false,"given":"Simona","family":"Vaitkien\u0117","sequence":"first","affiliation":[{"name":"Department of Biochemistry Vytautas Magnus University  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neringa","family":"Kulie\u0161ien\u0117","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vytautas Magnus University  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Sakalauskait\u0117","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vytautas Magnus University  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Bekere","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Krasnova","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigita","family":"Vigante","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunars","family":"Duburs","sequence":"additional","affiliation":[{"name":"Latvian Institute of Organic Synthesis  Riga Latvia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rimantas","family":"Daugelavi\u010dius","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Vytautas Magnus University  Kaunas Lithuania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00076-09"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.17-22047"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2014.07.001"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2010.06.014"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1469-0691.12495"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/21505594.2015.1039885"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6CC08657H"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-022X(84)90032-0"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.02535-18"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules23061459"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-6515-1_2"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000453134"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamem.2017.01.022"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/11.5.427"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05630"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.7124\/bc.00092B"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408347.2018.1537120"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/10520290701714013"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.4161\/viru.22913"},{"key":"e_1_2_8_21_1","first-page":"155","article-title":"Acid dissociation constants of N\u2010alkyl p\/o\u2010hydroxy styryl pyridinium dyes in surfactant solutions","volume":"40","author":"Mishra B. 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