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So far, ASC\u2010J9 has been investigated in typical AR\u2010associated diseases such as prostate cancer, benign prostatic hypertrophy, bladder cancer, renal diseases, liver diseases, cardiovascular diseases, cutaneous wound, spinal and bulbar muscular atrophy, ovarian cancer and melanoma, exhibiting great potentials in disease control. In this review, the effects and molecular mechanisms of ASC\u2010J9 on various AR\u2010associated diseases are summarized. Importantly, the effects of ASC\u2010J9 and AR antagonists enzalutamide\/bicalutamide on prostate cancer are compared in detail and crucial differences are highlighted. 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