{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T16:42:34Z","timestamp":1788540154378,"version":"build-2803163510"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2021,5,26]],"date-time":"2021-05-26T00:00:00Z","timestamp":1621987200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2021,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>A series of novel mandelic acid derivatives containing a 1,3,4\u2010oxadiazothioether moiety were designed and synthesized. Bioassay results showed that some target compounds exhibited certain antifungal activity against six kinds of pathogenic fungi in vitro. Among the compounds, the EC<jats:sub>50<\/jats:sub> values of <jats:bold>T<jats:sub>41<\/jats:sub><\/jats:bold> against <jats:italic>Gibberella saubinetii<\/jats:italic>, <jats:italic>Verticillium dahlia<\/jats:italic> and <jats:italic>Sclerotinia sclerotiorum<\/jats:italic> were 31.0, 27.0 and 32.1\u00a0\u03bcg\/ml, respectively, and the EC<jats:sub>50<\/jats:sub> value of <jats:bold>T<jats:sub>14<\/jats:sub><\/jats:bold> against <jats:italic>S. sclerotiorum<\/jats:italic> was 14.7\u00a0\u03bcg\/ml. The antifungal activity against the resistant fungus <jats:italic>S. sclerotiorum<\/jats:italic> indicated that this series of target compounds may have the similar action modes or sites as the commercialized succinate dehydrogenase inhibitor carboxin. A morphological study with fluorescence microscope demonstrated that <jats:bold>T<jats:sub>41<\/jats:sub><\/jats:bold> can significantly destroy the membrane integrity of <jats:italic>G<\/jats:italic>. <jats:italic>saubinetii<\/jats:italic>.<\/jats:p>","DOI":"10.1111\/cbdd.13861","type":"journal-article","created":{"date-parts":[[2021,5,9]],"date-time":"2021-05-09T22:57:56Z","timestamp":1620601076000},"page":"166-174","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Design, synthesis and antifungal evaluation of novel mandelic acid derivatives containing a 1,3,4\u2010oxadiazothioether moiety"],"prefix":"10.1111","volume":"98","author":[{"given":"Shuaitao","family":"Hou","sequence":"first","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dewen","family":"Xie","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Sciences Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingxin","family":"Yang","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue","family":"Niu","sequence":"additional","affiliation":[{"name":"School of Chemistry and Chemical Engineering Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deyu","family":"Hu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhibing","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering Key Laboratory of Green Pesticide and Agricultural Bioengineering Ministry of Education Center for R&amp;D of Fine Chemicals of Guizhou University  Guiyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,5,26]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.8b03020"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201800282"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.5873"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127028"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.201600501"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/1574-6968.12504"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/chir.23018"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1094\/PDIS-05-15-0499-RE"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.17221\/83\/2015-PPS"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.1187"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2019.126945"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jafc.7b06061"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2014.02.060"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/ps.4762"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12181"},{"key":"e_1_2_7_17_1","first-page":"1","article-title":"Whole cell\u2010based cascade biotransformation for the production of (S)\u2010mandelic acid from styrene, L\u2010phenylalanine, glucose, or glycerol","volume":"361","author":"Lukito B. 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