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Inflammation, one of the important mechanisms related to aging, is associated with osteoporosis. Treatment with anti\u2010inflammatory agents is effective for alleviating senile osteoporosis. Alginate oligosaccharide (AOS) can prevent and treat diseases related to inflammation, oxidative stress, and immunity. This study evaluates the effect of AOS on osteoporosis and investigates the underlying mechanism. Osteoporosis model was induced by D\u2010galactose (D\u2010gal) (200\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>) for eight weeks. Three groups were administered via AOS (50, 100, and 150\u00a0mg\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>) for four weeks, while a control group received sterile water (5\u00a0ml\u00a0kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>) for 8\u00a0weeks. The results showed that AOS improved bone density and bone microstructure in D\u2010gal\u2010induced osteoporosis mice. AOS inhibited osteoclast proliferation, probably through the suppression of receptor activator of nuclear factor\u2010kappa B ligand (RANKL)\u2010associated nuclear factor kappa B (NF\u2010\u03baB) and c\u2010Fos signaling pathway. AOS also increased osteoprotegerin (OPG) expression and competitively inhibited the binding between RANK and RANKL in senile osteoporosis. Further, AOS decreased the secretion of serum osteocalcin and reduced bone conversion. Together, these results demonstrate the anti\u2010osteoporosis activity of AOS in mice with osteoporosis.<\/jats:p>","DOI":"10.1111\/cbdd.13904","type":"journal-article","created":{"date-parts":[[2021,6,19]],"date-time":"2021-06-19T05:23:57Z","timestamp":1624080237000},"page":"46-55","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Alginate oligosaccharide alleviates senile osteoporosis via the RANKL\u2013RANK pathway in D\u2010galactose\u2010induced C57BL\/6J mice"],"prefix":"10.1111","volume":"99","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6560-5786","authenticated-orcid":false,"given":"Shan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"},{"name":"Department of Epidemiology and Health Statistics The School of Public Health of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianya","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of General Practice Anyang District Hospital of Puyang City  Anyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xufu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengxiu","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiping","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nina","family":"An","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongjun","family":"Mao","sequence":"additional","affiliation":[{"name":"Department of Geriatric Medicine The Affiliated Hospital of Qingdao University  Qingdao China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,11,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00911"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/md17050290"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.foodchem.2014.05.053"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2019.1702973"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1087057116654657"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/md14120231"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S142118"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.109"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11914\u2010019\u201000556\u20104"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598\u2010019\u201050679\u2010y"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/sctm.17\u20100054"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00198\u2010019\u201005200\u20106"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.04.010"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1242\/dmm.025247"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2005.08.047"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00060"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00861"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010349"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40266\u2010019\u201000714\u20104"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2019.04.022"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s004030050434"},{"key":"e_1_2_8_23_1","first-page":"449","article-title":"NF\u2010kappa B in aging and disease","volume":"2","author":"Tilstra J. 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