{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:46:25Z","timestamp":1787013985105,"version":"build-2736575974"},"reference-count":17,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2021,7,29]],"date-time":"2021-07-29T00:00:00Z","timestamp":1627516800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2021,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Natural diphyllin glycosides were identified as potent vacuolar H\n                    <jats:sup>+<\/jats:sup>\n                    \u2010ATPase (V\u2010ATPase) inhibitors. A series of diphyllin \u03b2\u2010hydroxyl amino derivatives were designed and synthesized as novel diphyllin derivatives. Most of these derivatives displayed potent cytotoxicity against six cancer cell lines with IC\n                    <jats:sub>50<\/jats:sub>\n                    values in the submicromolar to nanomolar concentration range. Compounds\n                    <jats:bold>2b<\/jats:bold>\n                    ,\n                    <jats:bold>2c<\/jats:bold>\n                    ,\n                    <jats:bold>2l<\/jats:bold>\n                    ,\n                    <jats:bold>2m<\/jats:bold>\n                    , and\n                    <jats:bold>2n<\/jats:bold>\n                    showed similar V\u2010ATPase inhibitory potency to\n                    <jats:bold>Bafilomycin A1<\/jats:bold>\n                    . Compound\n                    <jats:bold>2l<\/jats:bold>\n                    exhibited potent activity of modulation of lysosomal pH and cytoplasmic pH.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.13920","type":"journal-article","created":{"date-parts":[[2021,7,7]],"date-time":"2021-07-07T15:05:50Z","timestamp":1625670350000},"page":"674-682","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis and evaluation of diphyllin \u03b2\u2010hydroxyl amino derivatives as novel V\u2010ATPase inhibitors"],"prefix":"10.1111","volume":"98","author":[{"given":"Li","family":"Zhu","sequence":"first","affiliation":[{"name":"School of Pharmacy Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yapeng","family":"Lu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Li","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Ling","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0115-9489","authenticated-orcid":false,"given":"Yu","family":"Zhao","sequence":"additional","affiliation":[{"name":"School of Pharmacy Nantong University Nantong China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,29]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2019.104198"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2016.1263850"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fitote.2012.09.018"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellbi.2009.05.004"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008\u20105472.CAN\u201007\u20101805"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13238\u2010010\u20100102\u20102"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201500019"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbabio.2016.02.010"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0040\u20104020(01)93074\u20101"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.25.2.575\u2010589.2005"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12307\u2010012\u20100108\u20109"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201012\u20102587"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/ja.2016.169"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2014.06.002"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cjoc.200790127"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12538"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2015.05.033"}],"container-title":["Chemical Biology &amp; 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