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Current treatments have several drawbacks: emerging resistance to the existing drugs, lack of efficacy, and toxic side effects. Therefore, new antiparasitic drugs are urgently needed to treat and control diseases that affect human health, such as malaria, Chagas disease, leishmaniasis, amebiasis, giardiasis schistosomiasis, and filariasis, among others. Quinoxaline is a compound containing a benzene ring and a pyrazine ring. The oxidation of both pyrazine ring nitrogens allows the obtention of quinoxaline 1,4\u2010di\u2010\n                    <jats:italic>N<\/jats:italic>\n                    \u2010oxides (QdNOs) derivatives. By modifying the chemical structure of these compounds, it is possible to obtain a wide variety of biological properties. This review investigated the activity of quinoxaline derivatives and QdNOs against different protozoan parasites and helminths. We also cover the structure\u2013activity relationship (SAR) and summarize the main findings related to their mechanisms of action from published works in recent years. However, further studies are needed to determine specific molecular targets. This review aims to highlight the new development of antiparasitic drugs with better pharmacological profiles than current treatments.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.13921","type":"journal-article","created":{"date-parts":[[2021,7,20]],"date-time":"2021-07-20T10:06:35Z","timestamp":1626775595000},"page":"683-699","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Current status of quinoxaline and quinoxaline 1,4\u2010di\u2010\n                    <i>N<\/i>\n                    \u2010oxides derivatives as potential antiparasitic agents"],"prefix":"10.1111","volume":"98","author":[{"given":"Jacqueline","family":"Soto\u2010S\u00e1nchez","sequence":"first","affiliation":[{"name":"Secci\u00f3n de Estudios de Posgrado e Investigaci\u00f3n Escuela Nacional de Medicina y Homeopat\u00eda Instituto Polit\u00e9cnico Nacional  Ciudad de M\u00e9xico 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