{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T02:06:30Z","timestamp":1788833190342,"version":"build-2803163510"},"reference-count":167,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100008552","name":"Haryana State Council for Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008552","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2022,12]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Over the past few decades, the dynamic progress in the synthesis and screening of heterocyclic compounds against various targets has made a significant contribution in the field of medicinal chemistry. Among the wide array of heterocyclic compounds, triazole moiety has attracted the attention of researchers owing to its vast therapeutic potential and easy preparation via copper and ruthenium\u2010catalyzed azide\u2010alkyne cycloaddition reactions. Triazole skeletons are found as major structural components in a different class of drugs possessing diverse pharmacological profiles including anti\u2010cancer, anti\u2010bacterial, anti\u2010fungal, anti\u2010viral, anti\u2010oxidant, anti\u2010inflammatory, anti\u2010diabetic, anti\u2010tubercular, and anti\u2010depressant among various others. Furthermore, in the past few years, a significantly large number of triazole hybrids were synthesized with various heterocyclic moieties in order to gain the added advantage of the improved pharmacological profile, overcoming the multiple drug resistance and reduced toxicity from molecular hybridization. Among these synthesized triazole hybrids, many compounds are available commercially and used for treating different infections\/disorders like tazobactam and cefatrizine as potent anti\u2010bacterial agents while isavuconazole and ravuconazole as anti\u2010fungal activities to name a few. In this review, we will summarize the biological activities of various 1,2,3\u2010triazole hybrids with copious oxygen\u2010containing heterocycles as lead compounds in medicinal chemistry. This review will be very helpful for researchers working in the field of molecular modeling, drug design and development, and medicinal chemistry.<\/jats:p>","DOI":"10.1111\/cbdd.13966","type":"journal-article","created":{"date-parts":[[2021,9,30]],"date-time":"2021-09-30T15:44:46Z","timestamp":1633016686000},"page":"843-869","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":61,"title":["A minireview of 1,2,3\u2010triazole hybrids with O\u2010heterocycles as leads in medicinal chemistry"],"prefix":"10.1111","volume":"100","author":[{"given":"Bhavna","family":"Saroha","sequence":"first","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gourav","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Chemistry Kurukshetra University  Kurukshetra India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meena","family":"Kumari","sequence":"additional","affiliation":[{"name":"Department of Chemistry Govt. 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