{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T11:38:54Z","timestamp":1792150734642,"version":"4.4.0"},"reference-count":23,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,1,27]],"date-time":"2022-01-27T00:00:00Z","timestamp":1643241600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Chem Biol Drug Des"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Identifying novel lead compounds in drug discovery has been challenging because of the rapid rise of drug resistance to the existing chemotherapeutics and a lack of understanding of complex metabolic pathways in the parasite. Integrating computational and experimental approaches has shown to be of great worth in identifying and developing novel promising pharmacophore hybrids. In this present research, a series of new 4\u2010(1\n                    <jats:italic>H<\/jats:italic>\n                    )\u2010pyridone\u2010derived antimalarial agents were designed based on recent reports and our preliminary findings through in silico studies. Two of the 4\u2010(\n                    <jats:italic>1H<\/jats:italic>\n                    )\u2010Pyridone derivatives showed potential to bind to the Q\n                    <jats:sub>0<\/jats:sub>\n                    site of the cytochrome bc1 complex and disrupt the mitochondrial electron transport chain. These compounds, along with previously synthesized compounds, exhibited significant inhibitory activities against the malaria parasite. Presently, seven compounds were successfully synthesized, characterized and these novel compounds have shown promise as antimalarial agents.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.13987","type":"journal-article","created":{"date-parts":[[2021,11,30]],"date-time":"2021-11-30T22:47:18Z","timestamp":1638312438000},"page":"674-687","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["In silico design, chemical synthesis and biological screening of novel 4\u2010(1\n                    <i>H<\/i>\n                    )\u2010pyridone\u2010based antimalarial agents"],"prefix":"10.1111","volume":"99","author":[{"given":"Oluwatosin","family":"Audu","sequence":"first","affiliation":[{"name":"Department of Chemistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andre","family":"Stander","sequence":"additional","affiliation":[{"name":"Department of Physiology University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olayinka","family":"Ajani","sequence":"additional","affiliation":[{"name":"Department of Chemistry College of Science and Technology Covenant University  Ota Nigeria"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Egieyeh","sequence":"additional","affiliation":[{"name":"School of Pharmacy University of the Western Cape  Cape Town South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"October","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Pretoria  Pretoria South Africa"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,1,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.00249\u201017"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25163584"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2533\/chimia.2017.213"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b01256"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc.12.177"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1416611112"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/978\u20101\u201062703\u2010673\u20103"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12936\u2010020\u201003411\u20105"},{"key":"e_1_2_8_10_1","unstructured":"Johnson C. 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