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The structure of the synthetic compounds was characterized by various spectroscopic methods. The final products of triazole\/quinoline hybrids and ((prop\u20102\u2010yn\u20101\u2010yloxy)methyl)benzene intermediates were screened for their antibacterial (<jats:italic>Staphylococcus aureus<\/jats:italic>, <jats:italic>Escherichia coli<\/jats:italic>, <jats:italic>Shigella flexneri<\/jats:italic>, and <jats:italic>Salmonella enterica<\/jats:italic>), antifungal (<jats:italic>Candida albicans<\/jats:italic>, <jats:italic>Saccharomyces cerevisiae<\/jats:italic>, and <jats:italic>Aspergillus fumigatus<\/jats:italic>), and cytotoxic activities. The best antifungal compounds exhibited minimum inhibitory concentration (MIC), in the range of 0.35\u20130.63\u00a0\u00b5M, against <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>cerevisiae<\/jats:italic> without any cytotoxic effect. These compounds can be selected as the potential candidates for treating invasive fungal infections caused by <jats:italic>S<\/jats:italic>.\u00a0<jats:italic>cerevisiae<\/jats:italic>, after further investigation. Preliminary <jats:italic>in silico<\/jats:italic> ADME studies also predicted the favorable pharmacokinetic attributes of most compounds.<\/jats:p>","DOI":"10.1111\/cbdd.14031","type":"journal-article","created":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T12:11:09Z","timestamp":1644581469000},"page":"935-946","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Synthesis and biological activity profile of novel triazole\/quinoline hybrids"],"prefix":"10.1111","volume":"100","author":[{"given":"Hoda","family":"Jamshidi","sequence":"first","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis &amp; Polymers Department of Chemistry Iran University of Science and Technology  Tehran Iran"},{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Reza","family":"Naimi\u2010Jamal","sequence":"additional","affiliation":[{"name":"Research Laboratory of Green Organic Synthesis &amp; Polymers Department of Chemistry Iran University of Science and Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maliheh","family":"Safavi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Iranian Research Organization for Science and Technology  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2694-3272","authenticated-orcid":false,"given":"Kimia","family":"RayatSanati","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9851-2658","authenticated-orcid":false,"given":"Parisa","family":"Azerang","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1221-4490","authenticated-orcid":false,"given":"Azar","family":"Tahghighi","sequence":"additional","affiliation":[{"name":"Medicinal Chemistry Laboratory Department of Clinical Research Pasteur Institute of Iran  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,2,21]]},"reference":[{"key":"e_1_2_7_2_1","volume-title":"Azoles\u2010synthesis, properties, applications and perspectives","author":"Ali A. 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