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There are a limited number of drugs available for the treatment of these diseases; however, their overuse has resulted in pathogenic resistance. Recent studies have indicated the repurposing of nitro\u2010containing compounds to be a new avenue into finding new treatments. In this study, new nitrofuranyl sulfonohydrazide derivatives were synthesized and evaluated for their in vitro antileishmanial and anticancer activities. The analogue <jats:bold>2h<\/jats:bold>, featuring biphenyl moiety exhibited selective (SI\u2009&gt;\u200910) submicromolar activity (IC<jats:sub>50<\/jats:sub> 0.97\u2009\u03bcM) against acute promyelocytic leukemia cells hence was identified anticancer hit. This study revealed no antileishmanial hit. 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