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Among natural naphthoquinones, lapachol, \u03b1\u2010lapachone, \u03b2\u2010lapachone, lawsone, juglone, and plumbagin have been evaluated for its potential as antitrypanosomal activities. The chemotherapeutic drugs available for combating human trypanosomiasis, that is, American trypanosomiasis and African trypanosomiasis caused by\n                    <jats:italic>Trypanosoma cruzi<\/jats:italic>\n                    and\n                    <jats:italic>Trypanosoma brucei<\/jats:italic>\n                    , respectively, and animal tripanosomosis caused by\n                    <jats:italic>Trypanosoma evansi<\/jats:italic>\n                    have a problem of drug resistance and several toxic effect. Therefore, search of alternative effective drug molecules, without toxic effects, have enthused the researchers for searching new drug entity with potential clinical efficacy. In the search for new antitrypanosomal compound, this review focuses on different natural quinones and their synthetic derivatives associated with antitrypanosomal studies. In this context, this review will be useful for the development of new antitrypanosomal drugs mainly based on different structural modification of natural and synthetic naphthoquinones.\n                  <\/jats:p>","DOI":"10.1111\/cbdd.14122","type":"journal-article","created":{"date-parts":[[2022,7,19]],"date-time":"2022-07-19T12:18:54Z","timestamp":1658233134000},"page":"786-817","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Natural naphthoquinones and their derivatives as potential drug molecules against trypanosome parasites"],"prefix":"10.1111","volume":"100","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4858-0449","authenticated-orcid":false,"given":"Ruma","family":"Rani","sequence":"first","affiliation":[{"name":"ICAR\u2010National Research Centre on Equines  Hisar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khushboo","family":"Sethi","sequence":"additional","affiliation":[{"name":"ICAR\u2010National Research Centre on Equines  Hisar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1455-4720","authenticated-orcid":false,"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICAR\u2010National Research Centre on Equines  Hisar India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9731-6228","authenticated-orcid":false,"given":"Rajender S.","family":"Varma","sequence":"additional","affiliation":[{"name":"Regional Center of Advanced Technologies and Materials Palacky University  Olomouc Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2958-2193","authenticated-orcid":false,"given":"Rajender","family":"Kumar","sequence":"additional","affiliation":[{"name":"ICAR\u2010National Research Centre on Equines  Hisar India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0MD00072H"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1248\/cpb.c19-00911"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.2174\/157341209787314936"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1039\/C6MD00216A"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40199-018-0207-3"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1080\/14786419.2018.1484458"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.06.027"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/0074-02760190389"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00982222"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1021\/jf050721n"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0103-50532009000100026"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2007.10.015"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2012.03.039"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2008.03.032"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2010.03.029"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2019.06.056"},{"key":"e_1_2_8_18_1","first-page":"1780","article-title":"Anti\u2010Trypanosoma cruzi compounds: Our contribution for the evaluation and insights on the mode of action of naphthoquinones and derivatives","volume":"25","author":"Silva E. 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